推荐产品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
ARFAG, monoclonal
形狀
buffered aqueous solution
分子量
antigen 18 kDa
物種活性
bovine, canine, rat, human
濃度
2 mg/mL
技術
western blot: 1-2 μg/mL using MDCK total cell extract.
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ARF6(382)
rat ... Arf6(79121)
一般說明
ARF6 is a member of the ADP-ribosylation factor (ARF) family. It is specifically involved in endocytosis of plasma membrane proteins.
Anti-ARF6 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma ARFAG produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a synthetic peptide. class III includes only human Arf6. The ADP-ribosylation factors (Arf) family of proteins, which belong to the Ras (rat sarcoma viral oncogene homolog) family, are low molecular weight proteins capable of binding GTP.
應用
Anti-ARF6 antibody, Mouse monoclonal has been used in:
- western blotting
- enzyme linked immunosorbent assay (ELISA)
- immunocytochemistry
Mouse Monoclonal Anti-ARF6 antibody can be used for western blot assays at 1-2μg/ml using MDCK cell extracts. The antibody can also be used for ELISA and immunocytochemistry.
生化／生理作用
ADP-ribosylation factor 6 (Arf6) is present at the plasma membrane and on endosomal membranes where it regulates the flow of trafficking into and out of the cell, and regulates the actin cytoskeleton on the plasma membrane. ARF6 activates phospholipase D (PLD) and phosphatidylinositol 4-phosphate 5-kinase (PIP5K) to generate phosphatidic acid and PIP2 (phosphotidylinositol 4,5-bisphosphate), respectively.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Arf6, RalA and BIRC5 protein expression in non small cell lung cancer.
Knizhnik, A.V., et al.
Molecular Biology, 45, 307-315 (2011)
Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse
Tagliatti E, et al.
eLife, 5, e10116-e10116 (2016)
Summer F Acevedo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(46), 15396-15402 (2015-11-21)
Alcohol use disorders (AUDs) affect people at great individual and societal cost. Individuals at risk for AUDs are sensitive to alcohol's rewarding effects and/or resistant to its aversive and sedating effects. The molecular basis for these traits is poorly understood.
Multiple Roles for Arf6: Sorting, Structuring, and Signaling at the Plasma Membrane
Donaldson JG
The Journal of biological chemistry, 278(43), 41573-41576 (2003)
D A Gonzalez et al.
Molecular psychiatry, 23(3), 621-628 (2017-06-14)
Ubiquitously expressed genes have been implicated in a variety of specific behaviors, including responses to ethanol. However, the mechanisms that confer this behavioral specificity have remained elusive. Previously, we showed that the ubiquitously expressed small GTPase Arf6 is required for
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