跳转至内容
Merck
所有图片(5)

主要文件

查看所有文档

A4393

Sigma-Aldrich

R-(−)-阿朴吗啡 盐酸盐 半水合物

calcined, ≥98% (with NaOH, titration)

登录查看公司和协议定价
所有图片(5)

About This Item

线性分子式:
C17H17NO2 · HCl · 1/2H2O
CAS号:
41372-20-7
分子量:
312.79
EC號碼:
206-243-0
MDL號碼:
MFCD00150904
分類程式碼代碼:
12352210
PubChem物質ID:
24278821
NACRES:
NA.77

品質等級

200

化驗

≥98% (with NaOH, titration)

形狀

calcined
 (Powder to Crystalline Powder)

儲存條件

protect from light
under inert gas

顏色

white to gray

mp

285-287 °C (lit.)

溶解度

H2O: ~10 mg/mL, clear, yellow-green

SMILES 字串

Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68

InChI

1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1

InChI 密鑰

CXWQXGNFZLHLHQ-DPFCLETOSA-N

基因資訊

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

正在寻找类似产品? 访问 产品对比指南

應用

R-(-)-阿朴吗啡盐酸半水化合物已用作多巴胺受体激动剂，研究对帕金森症大鼠旋转行为的影响。

生化／生理作用

R-(−)-阿朴吗啡是一种非选择性的D1和D2多巴胺受体激动剂。它对帕金森病和男性勃起功能障碍有治疗作用。R-(−)-阿朴吗啡还具有神经保护、自由基清除和催吐作用。阿朴吗啡可刺激大脑的化学感受器触发区。它会刺激大脑中的化学感受器触发区。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

防範說明

P301 + P310

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCB4167
SLBP2436V
SLBP2431V
SLBF5500V
SLBF6369V

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

其他客户在看

Slide 1 of 2

1 of 2

木兰花碱 ≥98% (HPLC)

Sigma-Aldrich

SMB00377

木兰花碱

(±)-SKF-38393 hydrochloride crystalline, ≥98% (HPLC)

Sigma-Aldrich

D047

(±)-SKF-38393 hydrochloride

Qian Li et al.
Neuron, 76(5), 1030-1041 (2012-12-12)
Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN)
Kristina Malinovskaja et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 83(3), 477-484 (2012-12-05)
The objective of this study was to test a drug delivery system that combines iontophoresis and cation-exchange fibers as drug matrices for the controlled transdermal delivery of antiparkinsonian drug apomorphine. Positively charged apomorphine was bound to the ion-exchange groups of
Fumitoshi Kodaka et al.
European journal of nuclear medicine and molecular imaging, 40(4), 574-579 (2012-12-15)
Dopamine D receptors (DRs) have two affinity states for endogenous dopamine, referred to as high-affinity state (D ), which has a high affinity for endogenous dopamine, and low-affinity state (D ). The density of D can be measured with (R)-2-CHO-N-n-propylnorapomorphine
Yanpeng Yuan et al.
Theranostics, 8(17), 4679-4694 (2018-10-04)
Autologous neural stem cells (NSCs) may offer a promising source for deriving dopaminergic (DA) cells for treatment of Parkinson's disease (PD). Methods: By using Sendai virus, human peripheral blood mononuclear cells (PBMNCs) were reprogrammed to induced NSCs (iNSCs), which were
Anthony C Vernon et al.
Methods in molecular biology (Clifton, N.J.), 711, 487-510 (2011-02-01)
Neurotoxin-based rodent models of Parkinson's disease (PD) are widely used for pre-clinical evaluation of novel therapeutics for PD and have provided insights into mechanisms underlying motor dysfunction and nigrostriatal degeneration in PD. Predominantly, magnetic resonance imaging (MRI) studies in such
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门