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A4386

Sigma-Aldrich

腺苷-5′-二磷酸 双环己铵盐

≥95% (HPLC), crystalline, bacterial

别名:

A2P5P, ADP

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About This Item

经验公式（希尔记法）:
C10H15N5O10P2 · 2C6H13N
CAS号:
102029-87-8
分子量:
625.55
MDL號碼:
MFCD00058338
分類程式碼代碼:
41106305
PubChem物質ID:
329770855
NACRES:
NA.51

生物源

bacterial

品質等級

200

化驗

≥95% (HPLC)

形狀

crystalline

溶解度

H2O: soluble, clear to slightly hazy, colorless to faintly yellow

儲存溫度

−20°C

SMILES 字串

NC1CCCCC1.NC2CCCCC2.Nc3ncnc4n(cnc34)[C@@H]5O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]5O

InChI

1S/C10H15N5O10P2.2C6H13N/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;2*7-6-4-2-1-3-5-6/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);2*6H,1-5,7H2/t4-,6-,7-,10-;;/m1../s1

InChI 密鑰

SCOUEIPNDLFPCX-IDIVVRGQSA-N

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應用

5′-二磷酸腺苷（ADP）是通过ATP合酶转化为ATP而参与能量储存和核酸代谢的腺嘌呤核苷酸。ADP通过其与ADP受体P2Y1、P2Y12和P2X1的相互作用影响血小板活化。 在通过ecto-ADP酶转化为腺苷后，通过腺苷受体抑制血小板活化。
腺苷-5′-二磷酸二环己胺盐已被用作发光测定（luminometry）中的标准品。它也已用于苏拉明抑制分析。

注意

稳定，不吸潮

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Béatrice Hechler et al.
Purinergic signalling, 7(3), 293-303 (2011-07-28)
Following vessel wall injury, platelets adhere to the exposed subendothelium, become activated and release mediators such as TXA(2) and nucleotides stored at very high concentration in the so-called dense granules. Released nucleotides and other soluble agents act in a positive
Sarah Jones et al.
British journal of haematology, 153(1), 83-91 (2011-02-22)
ADP is considered a weak platelet agonist due to the limited aggregation responses it induces in vitro at physiological concentrations of extracellular Ca(2+) [(Ca(2+) )(o) ]. Lowering [Ca(2+) ](o) paradoxically enhances ADP-evoked aggregation, an effect that has been attributed to
David Iyú et al.
Arteriosclerosis, thrombosis, and vascular biology, 31(2), 416-422 (2010-11-26)
To investigate whether adenosine diphosphate (ADP)-derived adenosine might inhibit platelet aggregation, especially in the presence of a P2Y₁₂ antagonist, where the effects of ADP at the P2Y₁₂ receptor would be prevented. Platelet aggregation was measured in response to thrombin receptor
David Erlinge
Advances in pharmacology (San Diego, Calif.), 61, 417-439 (2011-05-19)
The purine- and pyrimidine-sensitive P2Y receptors belong to the large group of G-protein-coupled receptors that are the target of approximately one-third of the pharmaceutical drugs used in the clinic today. It is therefore not unexpected that the P2Y receptors could

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