生物源
human
品質等級
化驗
≥96% (agarose gel electrophoresis)
形狀
lyophilized powder
分子量
monomer calculated mol wt 66478 Da
技術
tissue culture: suitable
雜質
HIV I and HIVII, HCV and HBsAg, tested negative
溶解度
H2O: soluble 50 mg/mL
UniProt登錄號
異物活動
Alkaline phosphatase ≤0.001 units/mg protein
Peroxidase ≤0.001 units/mg protein
Protease ≤0.0001 units/mg protein
儲存溫度
2-8°C
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI 密鑰
QYSGYZVSCZSLHT-UHFFFAOYSA-N
基因資訊
human ... ALB(213)
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一般說明
Albumin is the most copious protein in blood plasma. Produced in the liver, serum albumin serves as a carrier protein for biomolecules like as fatty acids, amino acids, and steroids.
This human serum albumin (HSA) product has been specially tested and evaluated to be low in the following properties:
Serum albumin is used in various applications related to molecular biology, notably as an inert protein stabilizer for stock solutions of enzymes and proteins of interest. In such applications, it is thus important for the HSA to be protease free, to maintain the integrity of the protein or enzyme of interest.
Protease-free HSA is especially useful for applications like:
(b) Nucleic acid hybridization
(c) Radioimmunoassay (RIA)
This human serum albumin (HSA) product has been specially tested and evaluated to be low in the following properties:
- Essentially protease-free / low protease content
- Low alkaline phosphatase content
- Low peroxidase content
Serum albumin is used in various applications related to molecular biology, notably as an inert protein stabilizer for stock solutions of enzymes and proteins of interest. In such applications, it is thus important for the HSA to be protease free, to maintain the integrity of the protein or enzyme of interest.
Protease-free HSA is especially useful for applications like:
- Enzyme assays
- Protein-based assays
- Protease-sensitive techniques such as:
(b) Nucleic acid hybridization
(c) Radioimmunoassay (RIA)
應用
Albumin was used to test its effect on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumonia. It has been clinically used in serious and often life-threatening conditions, such as shock and blood loss due to trauma, burns, and surgery.
It was used to test the effect of non-enzymatic glycation on the unfolding of human serum albumin. It was also used to test the two distinct pathways used by intestinal epithelial cells for HLA class II antigen processing.
It was used to test the effect of non-enzymatic glycation on the unfolding of human serum albumin. It was also used to test the two distinct pathways used by intestinal epithelial cells for HLA class II antigen processing.
生化／生理作用
血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白，对调节血液的胶体渗透压至关重要。研究还发现白蛋白可结合外源物质，特别是药物（例如布洛芬、华法林），并强烈影响其药代动力学。导致白蛋白氧化还原状态变化的氧化应激对其生理功能具有广泛的影响。
特點和優勢
- Low protease activity / essentially protease-free (≤ 0.0001 units/mg protein)
- Low alkaline phosphatase activity (≤ 0.001 units/mg protein)
- Low peroxidase activity (≤ 0.001 units/mg protein)
準備報告
Prepared from A1653
其他說明
更多信息参见人血清白蛋白。
免責聲明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves
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R M Hershberg et al.
The Journal of clinical investigation, 100(1), 204-215 (1997-07-01)
Intestinal epithelial cells express a low level of HLA class II molecules constitutively, with elevated levels seen in the setting of mucosal inflammation including inflammatory bowel disease. The ability of intestinal epithelial cells to act as antigen presenting cells for
Deanna L Mendez et al.
Archives of biochemistry and biophysics, 444(2), 92-99 (2005-11-29)
We monitored the unfolding of human serum albumin (HSA) and glycated human serum albumin (gHSA) subjected to guanidine hydrochloride (GndHCl) by using fluorescence and circular dichroism (CD) spectroscopy. A two-state model with sloping baselines best described the Trp-214 fluorescence unfolding
D Sevillano et al.
The Journal of antimicrobial chemotherapy, 60(1), 156-158 (2007-05-08)
Attempts to interpret antibiotic pharmacodynamics using reported protein binding may underestimate true activity. To elucidate this issue we examined bacterial killing kinetics at cefditoren concentrations equal to C(max) in the presence of 90% human serum or albumin at physiological concentrations.
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