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A2478

Sigma-Aldrich

APHA Compound 8

solid, ≥98% (HPLC)

别名:

3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide

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About This Item

经验公式（希尔记法）:
C16H16N2O3
CAS号:
676599-90-9
分子量:
284.31
分類程式碼代碼:
12352202
PubChem物質ID:
329770785
NACRES:
NA.77

product name

APHA Compound 8, ≥98% (HPLC), solid

化驗

≥98% (HPLC)

形狀

solid

溶解度

DMSO: >10 mg/mL
H2O: insoluble

儲存溫度

2-8°C

SMILES 字串

Cn1cc(cc1\C=C\C(=O)NO)C(=O)Cc2ccccc2

InChI

1S/C16H16N2O3/c1-18-11-13(10-14(18)7-8-16(20)17-21)15(19)9-12-5-3-2-4-6-12/h2-8,10-11,21H,9H2,1H3,(H,17,20)/b8-7+

InChI 密鑰

UFQOXIMRSMFQRI-BQYQJAHWSA-N

生化／生理作用

One of a class of aroyl pyrrole hydroxy amide (APHA) compounds showing histone deacetylase (HDAC) inhibition, Compound 8 is the most potent and HDAC class I-selective.

象形圖

CorrosionExclamation mark
GHS05,GHS07

訊號詞

Danger

危險聲明

H302,H317,H318

危險分類

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Seiji Kuroda et al.
Molecular therapy. Methods & clinical development, 17, 612-621 (2020-04-18)
Non-toxic herpes simplex virus (HSV) vectors can be generated by functional deletion of all immediate-early (IE) genes, providing a benign vehicle with potential for gene therapy. However, deletion of multiple IE genes raises manufacturing concerns and thus limits clinical application

商品

Histone Modification and Chromatin Remodeling | Epigenetics

Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.

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