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42602

Sigma-Aldrich

丙酰-L-肉碱

≥94.0% (HPLC), suitable for LC/MS

别名:

(2 R )-3-羧基- N 、 N 、 N -三甲基-2-（1-氧代丙氧基）-1-丙胺 内盐, L -肉碱丙酰基酯, C3-肉碱, 丙酰- L -肉碱

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About This Item

经验公式（希尔记法）:
C10H19NO4
CAS号:
20064-19-1
分子量:
217.26
MDL號碼:
MFCD00870024
分類程式碼代碼:
12352209
PubChem物質ID:
329756246
NACRES:
NA.26

产品名称

丙酰-L-肉碱, ≥94.0% (HPLC)

品質等級

100

化驗

≥94.0% (HPLC)

形狀

powder or crystals

光學活性

[α]/D -23±3°, c = 1 in H2O

技術

LC/MS: suitable

雜質

≤10% water (calcd. from elemental analysis)

顏色

white to off-white

儲存溫度

2-8°C

SMILES 字串

[O-]C(C[C@@H](OC(CC)=O)C[N+](C)(C)C)=O

InChI

1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1

InChI 密鑰

UFAHZIUFPNSHSL-MRVPVSSYSA-N

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相关类别

一般說明

L-丙酰肉碱(PLC)是肉碱的短链脂肪酸酯衍生物。

應用

L-丙酰肉碱已用作液相色谱串联质谱(LC-MS/MS)的标准品。

生化／生理作用

L-丙酰肉碱(PLC)在脂质和糖类代谢中起重要作用。它为缺血性肌肉提供能量生产和ATP合成底物。丙酰肉碱可用于治疗严重的外周动脉疾病和慢性心力衰竭。丙酰肉碱与甲基丙二酸在甲基丙二酸单酰辅酶A变位酶(MUT)缺乏患者的尿中均以高丰度存在。MUT是一种线粒体酶，催化甲基丙二酰辅酶A异构化为琥珀酰辅酶A。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCB9653
BCBZ8342
BCBX4946
BCBV0261
BCBT4096

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Santica M Marcovina et al.
Translational research : the journal of laboratory and clinical medicine, 161(2), 73-84 (2012-11-10)
Mitochondria play important roles in human physiological processes, and therefore, their dysfunction can lead to a constellation of metabolic and nonmetabolic abnormalities such as a defect in mitochondrial gene expression, imbalance in fuel and energy homeostasis, impairment in oxidative phosphorylation
M J Cipolla et al.
Journal of vascular surgery, 29(6), 1097-1103 (1999-06-09)
The vasoactive effects of propionyl-L-carnitine (PLC) on human arteries, including endothelial and smooth muscle cell influences, were studied. Small (less than 200 microm) subcutaneous fat arteries (n = 19), obtained from human patients undergoing vascular surgery, were dissected and mounted
William R Hiatt et al.
Journal of cardiopulmonary rehabilitation and prevention, 31(2), 125-132 (2010-09-24)
Exercise training is established for the treatment of peripheral artery disease; however the additional benefit of pharmacologic therapy with exercise has not been studied. This trial tested the hypothesis that propionyl-L-carnitine (PLC), in combination with monitored home-based exercise training, would
Qixiao Jiang et al.
Environmental toxicology and pharmacology, 48, 116-124 (2016-10-25)
Perfluorooctanoic acid (PFOA), a persistent organic pollutant, is associated with developmental toxicity. This study investigated the mechanism of PFOA-induced developmental cardiotoxicity in chicken embryo, focusing on the interactions between developmental exposure to PFOA and the levels of l-carnitine (LC), acetyl-l-carnitine
Josiane Joseph et al.
Metabolites, 8(4) (2018-10-05)
Duchenne muscular dystrophy (DMD) is a musculoskeletal disorder that causes severe morbidity and reduced lifespan. Individuals with DMD have an X-linked mutation that impairs their ability to produce functional dystrophin protein in muscle. No cure exists for this disease and
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