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21279

Sigma-Aldrich

花萼海绵诱癌素A 来源于花萼国皮海绵

≥90% (HPLC)

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About This Item

经验公式（希尔记法）:
C50H81N4O15P
CAS号:
101932-71-2
分子量:
1009.17
Beilstein:
4903216
MDL號碼:
MFCD06795864
分類程式碼代碼:
12352200
PubChem物質ID:
329752128
NACRES:
NA.77

化驗

≥90% (HPLC)

形狀

solid

儲存溫度

−20°C

SMILES 字串

COC[C@@H]([C@H](O)[C@H](O)C(=O)NCC[C@H](C)c1nc(\C=C\C[C@@H]2O[C@]3(C[C@@H](O)[C@@H]2C)OC([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C(C)=C\C=C\C(C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)co1)N(C)C

InChI

1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1

InChI 密鑰

FKAWLXNLHHIHLA-YCBIHMBMSA-N

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生化／生理作用

1型和2A型蛋白磷酸酶抑制剂；海洋毒素，强效肿瘤促进剂。

其他說明

蛋白磷酸酶1和2A的有效抑制剂。 Pp1的功效是冈田酸的十倍以上

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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L.C. Starke et al.
The American Journal of Physiology, 264 (1993)
A V Mel'nitskaia et al.
Tsitologiia, 54(2), 143-148 (2012-05-18)
Using voltage-clamp technique, the possible role of the cytoskeleton in the effect of pharmacological analogue of oxidized glutathione (GSSG), drug glutoxim, on Na+ transport in the frog Rana temporaria skin was investigated. It was shown for the first time that
Lucas H Ting et al.
American journal of physiology. Heart and circulatory physiology, 302(11), H2220-H2229 (2012-03-27)
Endothelial cells respond to fluid shear stress through mechanotransduction responses that affect their cytoskeleton and cell-cell contacts. Here, endothelial cells were grown as monolayers on arrays of microposts and exposed to laminar or disturbed flow to examine the relationship among
Carole A Farah et al.
Journal of neurochemistry, 123(3), 360-372 (2012-08-24)
Protein kinase Cs (PKCs) are critical signaling molecules controlled by complex regulatory pathways. Herein, we describe an important regulatory role for C2 domain phosphorylation. Novel PKCs (nPKCs) contain an N-terminal C2 domain that cannot bind to calcium. Previously, we described
Koji Ashizawa et al.
Theriogenology, 79(3), 558-565 (2012-12-19)
Potential mechanisms of the reversible temperature-dependent immobilization of fowl sperm were investigated. At 30 °C, motility of demembranated fowl sperm was inhibited by adding 2 mM ethylene glycol-bis (2-aminoethylether)-N,N,N',N'-tetraacetic acid (EGTA), but restored immediately after the subsequent addition of 2
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