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16859

Sigma-Aldrich

2-羟基-D-谷氨酸 二钠盐

≥98.0% (GC)

别名:

（R）-2-羟基戊二酸, （R）-2-羟基戊二酸二钠

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About This Item

线性分子式:
C5H6O5Na2
CAS号:
103404-90-6
分子量:
192.08
Beilstein:
5318041
MDL號碼:
MFCD00069573
分類程式碼代碼:
12352106
PubChem物質ID:
329751400
NACRES:
NA.25

品質等級

100

化驗

≥98.0% (GC)

形狀

powder or crystals

光學活性

[α]/D 8.5±1.5°, c = 1 in NaOH

雜質

≤6.0% water

儲存溫度

2-8°C

SMILES 字串

[Na].O[C@H](CCC(O)=O)C(O)=O

InChI

1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1

InChI 密鑰

DZHFTEDSQFPDPP-HWYNEVGZSA-L

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生化／生理作用

代谢和癌症先天性错误的生物标志物

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Stefan Nowicki et al.
The FEBS journal, 282(15), 2796-2805 (2015-04-14)
Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis. Recently, metabolites that can
Seth J Parker et al.
Pharmacology & therapeutics, 152, 54-62 (2015-05-10)
Specific point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in a variety of cancers, including acute myeloid leukemia (AML), low-grade gliomas, and chondrosarcomas. These mutations inactivate wild-type enzymatic activity and convey neomorphic function to produce d-2-hydroxyglutarate
M S Rashed et al.
Biomedical chromatography : BMC, 14(5), 317-320 (2000-08-29)
D-2-Hydroxyglutaric aciduria and L-2-hydroxyglutaric aciduria are two distinct inherited metabolic diseases. The accurate diagnosis of the exact disorder relies on the determination of the configuration of the enantiomers, either D-2-hydroxyglutaric acid or L-2-hydroxyglutaric acid excreted in excess in urine of
Martijn Kranendijk et al.
Journal of inherited metabolic disease, 35(4), 571-587 (2012-03-07)
The organic acidurias D: -2-hydroxyglutaric aciduria (D-2-HGA), L-2-hydroxyglutaric aciduria (L-2-HGA), and combined D,L-2-hydroxyglutaric aciduria (D,L-2-HGA) cause neurological impairment at young age. Accumulation of D-2-hydroxyglutarate (D-2-HG) and/or L-2-hydroxyglutarate (L-2-HG) in body fluids are the biochemical hallmarks of these disorders. The current
Andrew J Worth et al.
Chemical research in toxicology, 28(5), 948-954 (2015-03-25)
The α-ketoglutarate metabolite, 2-hydroxyglutarate (2-HG), has emerged as an important mediator in a subset of cancers and rare inherited inborn errors of metabolism. Because of potential enantiospecific metabolism, chiral analysis is essential for determining the biochemical impacts of altered 2-HG
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