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15205

Sigma-Aldrich

杀稻瘟素S 盐酸盐

别名:

杀稻瘟菌素S

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About This Item

经验公式（希尔记法）:
C17H26N8O5 · HCl
CAS号:
3513-03-9
分子量:
458.90
MDL號碼:
MFCD02091640
分類程式碼代碼:
51101500
PubChem物質ID:
57647341

形狀

powder

品質等級

200

顏色

white to off-white

溶解度

acetic acid: water: soluble, clear, colorless

抗生素活性譜

fungi

應用

agriculture
environmental

作用方式

protein synthesis | interferes

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

Cl[H].CN(CC[C@@H](N)CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(O)=O)N2C=CC(N)=NC2=O)C(N)=N

InChI

1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1

InChI 密鑰

YQXYQOXRCNEATG-ZAYJLJTISA-N

相关类别

一般說明

化学结构：核苷
杀稻瘟素S属于抗生素的氨酰基核苷类。它抑制细菌和真核生物中的蛋白质合成。它还具有杀真菌特性，可预防稻瘟病。

應用

杀稻瘟菌素 S 用作含有抗性基因 bls、bsr 或 BSD 的转化细胞的选择剂。 杀稻瘟菌素 S 已用于选择具有 TLR-2 构建体的 HEK293-T 细胞和 HEK-D5 细胞。 也用于研究肽键形成水平上的蛋白质合成。

生化／生理作用

杀稻瘟素S抑制释放因子诱导的肽基tRNA水解。它增强了tRNA与核糖体大亚基的结合，并在一定程度上抑制了肽键的形成。

包裝

无底玻璃瓶。内含物装在锥底内插管中。

其他說明

保存于密闭容器内，置于干燥通风处。置于干燥处保存。储存类别（TRGS 510）：不可燃，急性毒性类别 1 和 2 /剧毒有害物质

相關產品

产品编号
说明
价格

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300

危險分類

Acute Tox. 1 Oral

儲存類別代碼

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Kamila Stokowa-Sołtys et al.
Journal of inorganic biochemistry, 127, 73-78 (2013-07-25)
Blasticidin S is a representative of the aminoacylnucleoside class of antibiotics and it possesses fungicidal properties against the virulent fungus which causes a serious rice blast disease in Asia. It is widely used to control rice blast by foliar application
Ana F David et al.
The Journal of cell biology, 218(7), 2150-2168 (2019-05-23)
Dividing cells reorganize their microtubule cytoskeleton into a bipolar spindle, which moves one set of sister chromatids to each nascent daughter cell. Early spindle assembly models postulated that spindle pole-derived microtubules search the cytoplasmic space until they randomly encounter a
Egor Svidritskiy et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(30), 12283-12288 (2013-07-05)
The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and performed biochemical and single-molecule FRET experiments to determine
Elizabeth J Meredith et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(36), 13485-13490 (2006-08-30)
Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their cytostatic response to the catecholamine and related, potentially therapeutic compounds. Proliferating normal lymphocytes and dividing malignant
James M Burke et al.
Molecular cell, 75(6), 1203-1217 (2019-09-09)
In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R (PKR) and ribonuclease L (RNase L) reprogram translation in mammalian cells. PKR inhibits translation initiation through eIF2α phosphorylation, which triggers stress granule (SG) formation and promotes translation of
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