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化驗
≥96.5% (HPLC)
96.5-103.5% (NT)
97%
形狀
powder
顏色
white to off-white
抗生素活性譜
fungi
yeast
作用方式
cell membrane | interferes
SMILES 字串
Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
InChI
1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
InChI 密鑰
QXHHHPZILQDDPS-UHFFFAOYSA-N
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相关类别
一般說明
Chemical structure: pyrimidine
應用
Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.
生化／生理作用
Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.
包裝
10G
其他說明
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Wenjiang Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(3), 314-318 (2002-02-21)
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal
Synergistic action of nikkomycin X/Z with azole antifungals on Candida albicans.
Slawomir Milewski, Fiorenzo Mignini, et. Al
Microbiology, 137, 2155-2161 (1991)
C Nolting et al.
Mycoses, 40 Suppl 1, 73-75 (1997-01-01)
We report on a 75 year old patient with a bronchial asthma treated at least for 15 years with low dose prednisolone. Under this treatment he developed a tinea follicularis and was demonstrated in our clinic with papulopustular skin lesions
Allergic contact dermatitis from tioconazole.
A Faria et al.
Contact dermatitis, 35(4), 250-252 (1996-10-01)
Karine Bourcier et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(6), 923-929 (2010-03-23)
Imidazoles and triazoles represent major classes of antifungal azole derivatives. With respect to UDP-glucuronosyltransferase (UGT) enzymes, the drug metabolism focus has mainly concentrated on their inhibitory effects with little known about azoles as substrates for UGTs. N-Glucuronide metabolites of the
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