agency
USP/NF
meets USP testing specifications
品質等級
應用
pharmaceutical (small molecule)
儲存溫度
2-8°C
SMILES 字串
CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InChI
1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
InChI 密鑰
GKCBAIGFKIBETG-UHFFFAOYSA-N
基因資訊
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
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應用
眼用局部麻醉药；用于脊髓麻醉
生化／生理作用
阻断 Ca2+ 从肌浆网的电压敏感性释放。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Howard Bregman et al.
Journal of medicinal chemistry, 54(13), 4427-4445 (2011-06-04)
Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Herein, we report structure-activity relationships for a novel series of 2,4-diaminotriazines that inhibit hNav1.7. Optimization
Lotta Salmela et al.
International journal of pharmaceutics, 472(1-2), 276-281 (2014-06-20)
We present a continuous-flow method that allows the release of drugs from submicron colloidal carriers to be estimated on a millisecond timescale. The technique is applied to the study of release of a model drug (tetracaine) from lipid emulsions, and
Ryan M Peters et al.
Journal of neurophysiology, 114(1), 264-273 (2015-05-01)
Galvanic vestibular stimulation (GVS) evokes a perception of rotation; however, very few quantitative data exist on the matter. We performed psychophysical experiments on virtual rotations experienced when binaural bipolar electrical stimulation is applied over the mastoids. We also performed analogous
Anna Taddio et al.
The Annals of pharmacotherapy, 36(4), 687-692 (2002-03-29)
To determine the relative efficacy of lidocaine-prilocaine and tetracaine for procedural pain in children. Systematic review was performed (MEDLINE1990-June 2001) of all studies comparing the efficacy of these 2 modalities of pain relief in children undergoing painful cutaneous procedures. Search
Yveline Henchoz et al.
Journal of medicinal chemistry, 51(3), 396-399 (2008-01-15)
Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds
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