推荐产品
等級
for molecular biology
品質等級
蒸汽壓力
<1 mmHg ( 20 °C)
產品線
Redi-Dri™
化驗
≥99% (titration)
形狀
crystalline powder
品質
free-flowing
pH值
6.2-7.8 (25 °C)
pKa (25 °C)
6.95
bp
256 °C (lit.)
mp
88-91 °C (lit.)
應用
diagnostic assay manufacturing
異物活動
DNase, RNase and protease, none detected
SMILES 字串
c1c[nH]cn1
InChI
1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
InChI 密鑰
RAXXELZNTBOGNW-UHFFFAOYSA-N
正在寻找类似产品? 访问 产品对比指南
一般說明
Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.
應用
Imidazole has been used
- in the lysis, wash, and elution buffer for the purification of histidine tagged proteins
- in gradient for the purification of histidine tagged proteins using nickel affinity chromatography
- as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells
特别适用于 pH 6.2-7.8 范围内的缓冲液
生化／生理作用
Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).
特點和優勢
- Qualified for molecular biology applications, DNase, Rnase, and protease free
- Redi-Dri™ packaging controls moisture, eliminating clumps
- Crystalline powder remains free-flowing and much easier to use
- Safer to handle and weigh out for routine use in lab
- Less waste, loss of drying, while maintaining high quality
其他說明
For additional information on our range of Biochemicals, please complete this form.
法律資訊
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 2
閃點（°F）
293.0 °F - closed cup
閃點（°C）
145 °C - closed cup
Molecular pathways regulating pro-migratory effects of Hedgehog signaling
Hochman E, et al.
The Journal of Biological Chemistry, 281(45), 33860-33870 (2006)
Bernd Zetsche et al.
Cell, 163(3), 759-771 (2015-10-01)
The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Class 1 effectors utilize multi-protein complexes, whereas class 2 effectors rely on single-component effector proteins such as the well-characterized Cas9. Here
Alan M Sandercock et al.
Molecular cancer, 14, 147-147 (2015-08-01)
Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screening platforms which are more predictive of
Pam M Van Ry et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(8), 1285-1297 (2015-06-09)
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by mutations in the dystrophin gene, leading to the loss of a critical component of the sarcolemmal dystrophin glycoprotein complex. Galectin-1 is a small 14 kDa protein normally found in skeletal
Ali Tebbi et al.
The Journal of biological chemistry, 290(22), 14077-14090 (2015-04-17)
Ribonucleotide reductase (RnR) is a key enzyme synthesizing deoxyribonucleotides for DNA replication and repair. In mammals, the R1 catalytic subunit forms an active complex with either one of the two small subunits R2 and p53R2. Expression of R2 is S
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门