PHR1764

秋水仙素

Pharmaceutical Secondary Standard; Certified Reference Material

• 别名: 秋水仙碱, (S)-N-(5,6,7,9-四氢-1,2,3,10-四甲氧基-9-氧苯并[a]庚搭烯-7-基）乙酰胺
• 经验公式（希尔记法）: C₂₂H₂₅NO₆
• CAS号: 64-86-8
• 分子量: 399.44
• Beilstein: 2228813
• EC號碼: 200-598-5
• MDL號碼: MFCD00078484
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329823598
• NACRES: NA.24

属性

• 等級: certified reference material; pharmaceutical secondary standard
• 品質等級: 300
• agency: traceable to BP 1150; traceable to Ph. Eur. C2580000; traceable to USP 1146006
• API 家族: colchicine, thiocolchicoside
• CofA: current certificate can be downloaded
• 包裝: pkg of 400 mg
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• mp: 150-160 °C (dec.) (lit.)
• 應用: pharmaceutical (small molecule)
• 格式: neat
• 儲存溫度: 2-8°C
• SMILES 字串: COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O
• InChI: 1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
• InChI 密鑰: IAKHMKGGTNLKSZ-INIZCTEOSA-N
• 基因資訊: human ... TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)

说明

一般說明

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Colchicine is a drug used for the treatment of gout and certain rheumatic and nonrheumatic conditions. It is the major alkaloid in the plant Colchicum autumnale (meadow saffron).

應用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Colchicine may be used as a pharmaceutical reference standard for the determination of colchicine in human plasma at therapeutic concentrations by liquid chromatography–tandem mass spectrometry method.

安全信息

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H300 - H340
• 防範說明: P202 - P264 - P280 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 2 Oral - Muta. 1B
• 儲存類別代碼: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable