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Merck

PHR1611

Supelco

巯嘌呤

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

6-巯基嘌呤 一水合物, 6-嘌呤硫醇, 6-硫代嘌呤

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About This Item

经验公式(希尔记法):
C5H4N4S·H2O
CAS号:
分子量:
170.19
Beilstein:
4012091
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to BP 773
traceable to USP 1392002

API 家族

mercaptopurine

CofA

current certificate can be downloaded

包裝

pkg of 1 g

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

O.S=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

InChI 密鑰

WFFQYWAAEWLHJC-UHFFFAOYSA-N

基因資訊

human ... PPAT(5471)

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一般說明

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mercaptopurine is an anticancer and an immunosuppressive drug employed for the management of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn′s disease, etc. Its mode of action involves interference in the nucleic acid synthesis by the inhibition of purine metabolism.

應用

Mercaptopurine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, suspensions, and double drug liposomes by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析報告

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAC3476 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Muta. 2 - Repr. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3


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分析证书(COA)

Lot/Batch Number

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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF MERCAPTOPURINE-AN ANTI CANCER DRUG IN PHARMACEUTICAL FORMULATIONS
Suman P, et al.
European Journal of Biomedical AND Pharmaceutical sciences, 5(5), 752-759 (2018)
Effect of buffer and antioxidant on stability of a mercaptopurine suspension
Aliabadi HM, et al.
American Journal of Health-System Pharmacy, 65(5), 441-447 (2008)
6-mercaptopurine and daunorubicin double drug liposomes?preparation, drug-drug interaction and characterization
Agrawal V, et al.
Journal of liposome research, 15(3-4), 141-155 (2005)
Mepivacaine hydrochloride
USP42-NF37
United States Pharmacopeia/National Formulary, 40(5), 2750-2750 (2019)

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