PHR1014

氢化可的松

Pharmaceutical Secondary Standard; Certified Reference Material

• 别名: 11β,17α,21-三羟基孕酮-4-烯-3,20-二酮, 17-羟基皮质酮标准液, 4-孕烯-11β,17α,21-三醇-3,20-二酮, 皮质醇标准液, 肯德尔氏化合物F, 赖希斯坦氏物质M
• 经验公式（希尔记法）: C₂₁H₃₀O₅
• CAS号: 50-23-7
• 分子量: 362.46
• Beilstein: 1354819
• EC號碼: 200-020-1
• MDL號碼: MFCD00011654
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329823045
• NACRES: NA.24

属性

• 等級: certified reference material; pharmaceutical secondary standard
• 品質等級: 300
• agency: traceable to BP 576; traceable to Ph. Eur. H1300000; traceable to USP 1316004
• API 家族: hydrocortisone
• CofA: current certificate can be downloaded
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• mp: 211-214 °C (lit.)
• 應用: pharmaceutical (small molecule)
• 格式: neat
• 儲存溫度: 2-30°C
• SMILES 字串: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI 密鑰: JYGXADMDTFJGBT-VWUMJDOOSA-N
• 基因資訊: human ... NR3C1(2908)

说明

一般說明

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydrocortisone is a degradation product of the corticosteroid, hydrocortisone acetate.

應用

Hydrocortisone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化／生理作用

肾上腺皮质分泌的原始糖皮质激素。它的抗炎效力是皮质酮的三倍，但 Na²⁺ 保留效力要低得多。

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

分析報告

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAB3713 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H360Df,H373
• 防範說明: P202 - P260 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 1A - STOT RE 2
• 標靶器官: Adrenal gland,Bone marrow
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable