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生物源
synthetic (chemical)
品質等級
化驗
89.0-100.5% anhydrous basis
形狀
powder
顏色
white to off-white
溶解度
H2O: 50 mg/mL
抗生素活性譜
Gram-negative bacteria
Gram-positive bacteria
作用方式
cell wall synthesis | interferes
儲存溫度
2-8°C
SMILES 字串
[Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)C(C([O-])=O)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
InChI
1S/C17H18N2O6S.2Na/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25);;/q;2*+1/p-2/t9?,10-,11+,14-;;/m1../s1
InChI 密鑰
RTYJTGSCYUUYAL-YCAHSCEMSA-L
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一般說明
羧苄青霉素是一种半合成、广谱羧基青霉素抗生素，具有杀菌和抗β－内酰胺酶活性。它是一种广谱抗生素，即它能够有效对抗各种细菌，包括革兰氏阳性和革兰氏阴性细菌。羧苄青霉素对铜绿假单胞菌特别有效，铜绿假单胞菌是一种可以耐受其它抗生素的革兰氏阴性菌。
羧苄青霉素常用于细胞生物学应用，可防止细菌污染物的生长。在微生物学中，它也用于选择以含有编码β－内酰胺酶基因的载体转化的细菌，这使其耐受羧苄青霉素。
羧苄青霉素常用于细胞生物学应用，可防止细菌污染物的生长。在微生物学中，它也用于选择以含有编码β－内酰胺酶基因的载体转化的细菌，这使其耐受羧苄青霉素。
應用
羧苄青霉素二钠盐已用于：
- 制备LB琼脂平板和培养基
- 作为培养基中的选择剂用于防止细菌污染物的生长
- 开发单克隆抗体的研究
生化／生理作用
作用机制：羧青霉素抗生素，可通过灭活细菌细胞膜内表面的转肽酶来抑制细菌细胞壁合成（肽聚糖交联）。
抗微生物谱：具有抗革兰氏阳性和革兰氏阴性细菌活性。
抗微生物谱：具有抗革兰氏阳性和革兰氏阴性细菌活性。
羧苄青霉素通过打开内酰胺环，酰化青霉素敏感性转肽酶（penicillin-sensitive transpeptidase）的C-末端结构域。这种钝化作用防止了肽聚糖束（peptidoglycan strand）的交联，从而抑制了细菌细胞壁合成的第三和最后阶段。这导致细菌细胞壁的不完全合成，最终导致细胞溶解。
特點和優勢
- 具有杀菌和抗β－内酰胺酶活性的广谱抗生素
- 有效对抗各种细菌，包括铜绿假单胞菌
- 常用于细胞生物学和生物化学应用
- 提供优于氨苄青霉素的稳定性
儲存和穩定性
密闭。干燥。上锁保存或放置在只有经过授权或有资质的人员才能进入的区域。
分析報告
在 37°C 下可稳定保存 3 天
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1 - Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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John R Zupan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), 9060-9065 (2013-05-16)
Growth and cell division in rod-shaped bacteria have been primarily studied in species that grow predominantly by peptidoglycan (PG) synthesis along the length of the cell. Rhizobiales species, however, predominantly grow by PG synthesis at a single pole. Here we
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Journal of molecular biology, 405(1), 173-184 (2010-10-27)
We report the first crystal structures of a penicillin-binding protein (PBP), PBP3, from Pseudomonas aeruginosa in native form and covalently linked to two important β-lactam antibiotics, carbenicillin and ceftazidime. Overall, the structures of apo and acyl complexes are very similar;
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