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Merck

BCR312

2-硝基-7-甲氧基萘并[2,1-b]呋喃

BCR®, certified reference material

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About This Item

经验公式(希尔记法):
C13H9NO4
CAS号:
分子量:
243.21
Beilstein:
5749492
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material

agency

BCR®

製造商/商標名

JRC

技術

HPLC: suitable
gas chromatography (GC): suitable

格式

neat

儲存溫度

2-8°C

SMILES 字串

COc1ccc2c(ccc3oc(cc23)[N+]([O-])=O)c1

InChI

1S/C13H9NO4/c1-17-9-3-4-10-8(6-9)2-5-12-11(10)7-13(18-12)14(15)16/h2-7H,1H3

InChI 密鑰

BRRIJZQYTOFDAF-UHFFFAOYSA-N

分析報告

For more information please see:
BCR312

法律資訊

BCR is a registered trademark of European Commission

象形圖

Health hazard

訊號詞

Warning

危險聲明

危險分類

Muta. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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P Quillardet et al.
Mutation research, 358(1), 113-122 (1996-10-28)
The influence of the uvr-dependent excision repair system on the lethal action, mutagenic specificity, SOS induction and DNA adducts formation of 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), a potent genotoxic nitrofuran, were examined in Escherichia coli. Binding measurements of 3H-labelled R7000 to DNA indicated
L Cui et al.
Cancer letters, 76(2-3), 161-166 (1994-01-30)
Among the nitro-naphthofurans, 7-methoxy-2-nitro-naphtho[2,1-b]furan (R7000) has proved to be a very potent mutagen that causes sarcomas at the subcutaneous injection site and carcinomas in the forestomach after p.o. administration. In the present study, possible promoting activity for diethylnitrosamine (200 mg/kg
R J Salmon et al.
Cancer letters, 35(1), 59-64 (1987-04-01)
7-Methoxy-2-nitro-naphtho[2,1-b]furan (R 7000) and its methylated homolog in position 1 (R 7372) are among the most mutagenic agents presently known, as shown by the results obtained both in the Ames test and in the SOS Chromotest. Their carcinogenic effects were
H Strapélias et al.
Carcinogenesis, 9(11), 1987-1993 (1988-11-01)
The metabolism of 7-methoxy-2-nitro-naphtho[2,1-b]furan and the subsequent binding to DNA, under aerobic conditions, were investigated using liver microsomes of both untreated rats and rats pre-treated with 3-methylcholanthrene [3-MC]. The metabolites were analyzed by HPLC. The following compounds: 7-hydroxy-2-nitro-naphtho[2,1-b]-furan-6,9-dione; 6,7-dihydro-2-nitro-naphtho[2,1-b]furan; 7-hydroxy-2-nitro-naphtho[2,1-b]furan
[In vitro antibacterial activity of 7-methoxy-2-nitronaphto [2,1-b]furan (R 7000)].
A Amgar et al.
Annales pharmaceutiques francaises, 41(3), 283-285 (1983-01-01)

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