917400

tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate

≥95%

• 别名: Semi-flexible linker for PROTAC^® development
• 经验公式（希尔记法）: C₁₇H₂₅NO₃
• CAS号: 909422-39-5
• 分子量: 291.39
• MDL號碼: MFCD30099260
• 分類程式碼代碼: 12352116
• NACRES: NA.22

属性

• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder
• 反應適用性: reagent type: linker
• 官能基: Boc; hydroxyl
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(N(CC1)CCC1C2=CC(CO)=CC=C2)OC(C)(C)C

说明

應用

tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

其他說明

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H315,H317,H319,H410
• 防範說明: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable