901425

White-Clark catalyst

• 别名: [MnIII(ClPc)]Cl
• 经验公式（希尔记法）: C₃₂Cl₁₇MnN₈
• CAS号: 2226663-68-7
• 分子量: 1154.04
• 分類程式碼代碼: 12161600
• NACRES: NA.22

属性

• 形狀: powder
• 反應適用性: reaction type: Cross Couplings; reagent type: catalyst; core: manganese

说明

應用

This catalyst is useful for late-stage functionalization of complex compounds through C-H amination. This catalyst is highly reactive and selective for amination at benzylic positions. The benzylic amination is highly selective over tertiary amination. In substrates with multiple benzylic sites, the preference is for amination at the least sterically encumbered and most electron rich site, irrespective of bond dissociation energy (BDE). Substrates containing basic nitrogen (tertiary amines, pyridine, benzimidazole) can be effectively protected for the first time using this catalyst with a Brønsted (HBF₄) or Lewis acid (BF₃), to give remotely aminated products. Late-stage amination has been demonstrated on a series of drugs and drug-like molecules, including citalopram, analogs of estrone and dextromethorphan, and biflavanoids, many of which cannot be accessed by other amination methods due to the presence of basic nitrogens.

其他說明

Manganese-catalysed benzylic C(sp³)–H amination for late-stage functionalization

法律資訊

This product is patent pending under application #62/569,872.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable