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應用
通过与蛋白酶形成复合物来抑制所有种类的内切蛋白酶。当蛋白酶切割巨球蛋白“诱饵”序列时，巨球蛋白重新排列并捕获蛋白酶。
生化／生理作用
α2-巨球蛋白在血浆和间质液中大量存在。蛋白酶-α2-M 平衡在介导炎症组织破坏中起重要作用。脓毒症、肺气肿、牙周炎、类风湿性关节炎和其他炎症性疾病患者的血清 α2-M 和蛋白酶-α2-M 复合物水平升高，而 α2-M 的氧化失活可能导致炎症期间的组织破坏。
分析報告
对每个供体的血浆都进行了检测，发现 HIV-1/HIV-2 抗体、HCV 抗体和 HbSAg 抗体均为阴性。
100 mg solids are lyophilized with 1 mg glycine from 35.2 mL 30 mM sodium phosphate, pH 7.0
其他說明
Conformational changes of α2-M
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
P A Roche et al.
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Treatment of the human plasma proteinase inhibitor alpha 2-macroglobulin (alpha 2M) with proteinase results in conformational changes in the inhibitor and subsequent activation and cleavage of the internal thiolester bonds of alpha 2M. Previous studies from this laboratory have shown
J J Feige et al.
Hormone research, 45(3-5), 227-232 (1996-01-01)
alpha 2-Macroglobulin (alpha 2M) is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M
Paul Dent et al.
Journal of cellular physiology, 235(10), 6862-6874 (2020-01-28)
We have extended our analyses of (curcumin+sildenafil) biology. The drug combination caused vascularization and degradation of mutant K-RAS that correlated with reduced phosphorylation of ERK1/2, AKT T308, mTORC1, mTORC2, ULK1 S757, STAT3, STAT5, and NFκB and increased phosphorylation of eIF2α
Alpha 2-macroglobulin.
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Yonathan Uriel et al.
Insect science, 27(2), 256-265 (2018-07-27)
We tested the recent hypothesis that the "fly factor" phenomenon (food currently or previously fed on by flies attracts more flies than the same type of food kept inaccessible to flies) is mediated by bacterial symbionts deposited with feces or
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