等級
analytical standard
品質等級
產品線
VETRANAL®
儲存期限
limited shelf life, expiry date on the label
技術
HPLC: suitable
gas chromatography (GC): suitable
mp
208 °C (dec.) (lit.)
應用
forensics and toxicology
pharmaceutical (small molecule)
形式
neat
SMILES 字串
CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O
InChI
1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+
InChI 密鑰
FLOSMHQXBMRNHR-QPJJXVBHSA-N
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應用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化／生理作用
Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.
法律資訊
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Saba J Elderkin et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 27(1), 70-73 (2010-06-15)
to report the successful treatment of two patients who developed flap necrosis preceded by recurrent epithelial ingrowth and interface fluid syndrome after LASIK. patient 1 was treated with epithelial debridement and flap suturing. Patient 2 was initially treated with epithelial
Harold J Bell et al.
Respiratory physiology & neurobiology, 171(3), 201-211 (2010-04-13)
The typical respiratory response to hypoxia includes a dramatic facilitation of augmented breaths (ABs) or 'sighs' in the breathing rhythm. We recently found that when acetazolamide treatment is used to promote CO(2) retention and counteract alkalosis during exposure to hypoxia
A novel medication error in the treatment of hyperthyroidism.
Bhavesh B Barad et al.
Tennessee medicine : journal of the Tennessee Medical Association, 106(2), 42-42 (2013-03-20)
Mohamed G Hassan et al.
Biomedical chromatography : BMC, 26(2), 214-219 (2011-05-20)
A sensitive high-performance liquid chromatographic method with fluorescence detection was developed to determine memantine (MT) in rat plasma. The method consists of pre-column labeling of MT with 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoyl chloride (DIB-Cl) and a clean-up step with solid-phase extraction. A good separation
Phatsawee Jansook et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 76(2), 208-214 (2010-07-20)
Topically applied carbonic anhydrase inhibitors (CAIs) are commonly used to treat glaucoma. However, their short duration of action requiring multiple daily dosing can hamper patient compliance. The aim of this study was to develop novel aqueous CAI eye drop formulation
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