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Merck
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文件

34219

Supelco

替莫唑胺

VETRANAL®, analytical standard

别名:

3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺, 3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺, 4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬基-2,7,9-三烯-9-甲酰胺, 8-氨甲酰-3-甲基咪唑[5,1-d]-1,2,3,5-四嗪-4(3H)-酮, NSC 362856

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About This Item

经验公式（希尔记法）:
C6H6N6O2
CAS号:
85622-93-1
分子量:
194.15
MDL號碼:
MFCD00866492
分類程式碼代碼:
41116107
PubChem物質ID:
329754905
NACRES:
NA.24

等級

analytical standard

品質等級

100

產品線

VETRANAL®

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

格式

neat

儲存溫度

2-8°C

SMILES 字串

CN1N=Nc2c(ncn2C1=O)C(N)=O

InChI

1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

InChI 密鑰

BPEGJWRSRHCHSN-UHFFFAOYSA-N

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一般說明

替莫唑胺可以称为口服烷基化剂和抗肿瘤药，在复发性神经胶质瘤或胶质母细胞瘤等肿瘤的治疗中显示出很强的活性。
替莫唑胺可以称为口服烷基化剂和抗肿瘤药，在复发性神经胶质瘤或胶质母细胞瘤（一种影响大脑或脊柱的肿瘤）的治疗中显示出很强的活性。

應用

有关合适仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务。

法律資訊

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

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分析证书(COA)

Lot/Batch Number
BCBZ8591
SZBF005XV
SZBC079XV
SZBA221XV
SZE8326X

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Stupp R, et al.
Journal of Clinical Oncology, 20, 1375-1382 (2002)
Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
Hehi.EM, et al.
Clinical Cancer Research, 10(6), 1871-1874 (2004)
Glioma: Principles and Practice in Neuro-Oncology (2012)
NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA
Denny.JB, et al.
BioChemistry: An Indian Journal, 33(31), 9045-9051 (1994)
Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide
Stupp R, et al.
Journal of Clinical Oncology, 20(5), 1375-1382 (2002)
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