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Merck
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11332

Sigma-Aldrich

阿托品 硫酸盐 一水合物

tested according to Ph. Eur.

别名:

硫酸阿托品, (8-甲基-8-氮杂双环[3.2.1]辛-3-基) edno-(+/-)-α-(羟甲基)苯乙酸酯, 龙葵碱

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About This Item

线性分子式:
(C17H23NO3)2 · H2SO4 · H2O
CAS号:
5908-99-6
分子量:
694.83
Beilstein:
6109275
EC號碼:
200-235-0
MDL號碼:
MFCD00074815
分類程式碼代碼:
12352200
PubChem物質ID:
329749385
NACRES:
NA.21

agency

USP/NF
tested according to Ph. Eur.

品質等級

200

mp

189-192 °C (A) (lit.)

溶解度

water: soluble 2500 g/L at 4 °C

應用

pharmaceutical (small molecule)

SMILES 字串

O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6

InChI

1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

InChI 密鑰

JPKKQJKQTPNWTR-CHYDPLAESA-N

基因資訊

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

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應用

Atropine sulfate salt monohydrate has been used for anaesthetizing mice for intranasal administration of ropinirole or 7-OH-DPAT.

生化／生理作用

Atropine sulfate salt monohydrate is a competitive nonselective antagonist of central and peripheral muscarinic acetylcholine receptors. Atropine is a cholinergic receptor antagonist isolated from Atropa belladona L., Datura stramonium L. and other plants of the solanaceae family. It blocks the ion currents mediated by neuronal nicotinic acetylcholine receptors. Further, it blocks the acetylcholine (ACh)-induced relaxations in human pulmonary veins.
位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300 + H330

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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分析证书(COA)

Lot/Batch Number
BCBZ4813
BCBX1616
BCBW4732
BCBT8628
BCBS9281V

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Chu Lan Lao et al.
Neurotoxicity research, 24(4), 523-531 (2013-07-04)
Parkinson's disease (PD) is a neurodegenerative disease with a hallmark motor defect caused by the death of dopaminergic neurons in the substantia nigra. Intranasal drug administration may be useful for Parkinson's treatment because this route avoids first-pass metabolism and increases
R Zwart et al.
Molecular pharmacology, 52(5), 886-895 (1997-11-14)
Atropine, the classic muscarinic receptor antagonist, inhibits ion currents mediated by neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. At the holding potential of -80 mV, 1 microM atropine inhibits 1 mM acetylcholine-induced inward currents mediated by rat alpha2beta2
F Trovero et al.
Toxicology and applied pharmacology, 150(2), 321-327 (1998-07-07)
This study consists of two parts, first to compare the pharmacological profile of atropine and CEB-1957 substance toward muscarinic receptor subtypes. In various rat brain structures, binding properties were determined by competition experiments of [3H]pirenzepine, [3H]AF-DX 384, and [3H]4-DAMP in
L Walch et al.
British journal of pharmacology, 130(1), 73-78 (2000-04-26)
1. To characterize the muscarinic receptors on human pulmonary veins associated with the acetylcholine (ACh)-induced relaxation, isolated venous and arterial preparations were pre-contracted with noradrenaline (10 microM) and were subsequently challenged with ACh in the absence or presence of selective
Miklós Palotai et al.
Neurochemical research, 39(8), 1477-1483 (2014-06-05)
The nociceptin/orphanin FQ peptide (NOP) receptor and its endogenous ligand plays role in several physiologic functions of the central nervous system, including pain, locomotion, anxiety and depression, reward and drug addiction, learning and memory. Previous studies demonstrated that the NOP-receptor
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