SCC624

Lacun.3 Mouse Lung Adenocarcinoma Cell Line

• 别名: Lacun.3 Mouse Lung Adenocarcinoma Cell Line, Lacun-3, Lacun3
• 分類程式碼代碼: 41106514

属性

• 生物源: mouse
• 品質等級: 100
• 包裝: vial of ≥1X10⁶ vial
• 製造商／商標名: Millipore
• 技術: cell culture | mammalian: suitable
• 運輸包裝: liquid nitrogen
• 儲存溫度: −196°C

说明

應用

• Each vial contains > 1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Essential CLEAR Panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for interspecies contamination from human, rat, Chinese hamster, Golden Syrian hamster, and nonhuman primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
• Cells are negative for mycoplasma contamination.

特點和優勢

Lacun.3 cells are capable of forming spheroids that can be maintained over multiple passages and display increased cancer stem cell characteristics including increased ALDH activity.

標靶描述

Recent cancer research often studies a newly characterized type of cell referred to as cancer stem cells (CSCs) or also sometimes termed tumor-initiating cells (TICs.) These cells appear to have significant capabilities to grow, differentiate, generate tumors and resist chemotherapy. Tumor sphere cultures (TSCs) have emerged as a new format of studying cancer as well as understanding CSCs. The spheroid structures of TSCs appear to induce stem-like characteristics evidenced by the increased expression of stem cell markers. This 3D spheroid structure is also a much more accurate way to mimic the behavior of a solid tumor which develops in 3-dimensions and behaves quite differently from a monolayer cell culture. Spheroids are understood to have more tumor-forming capabilities when compared to monolayer cultures, yet the underlying mechanism for these characteristics is still under study. Stem-cell like properties, such as increased aldehyde dehydrogenase activity (ALDH), have already been used to identify CSCs in a variety of cancer types.

儲存和穩定性

Lacun.3 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages without significantly affecting cell marker expression and function.

其他說明

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@milliporesigma.com.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable