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描述
The analytes available for this multiplex kit are: Liver-type arginase 1 (ARG1), aspartate transaminase 1 (GOT1), α-glutathianone S-transferase (GSTα), sorbitol dehydrogenase (SDH), and 5′-Nucleotidase (5′-NT/CD73).
品質等級
物種活性
rat
製造商／商標名
Milliplex®
assay range
accuracy: 77-92%
sensitivity: 0.021-4.038 ng/mL
(MinDC+2SD)
standard curve range: 0.02-15.0 ng/mL
(GSTα)
standard curve range: 0.04-30.0 ng/mL
(5′-NT/CD73)
standard curve range: 0.08-60.0 ng/mL
(GOT1)
standard curve range: 0.10-75.0 ng/mL
(ARG1)
standard curve range: 0.62-450.0 ng/mL
(SDH)
技術
multiplexing: suitable
檢測方法
fluorometric (Luminex xMAP)
運輸包裝
wet ice
一般說明
*ARG1, GSTα, and SDH are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing.
The MILLIPLEX® portfolio provides a valuable research assay to investigate multiple biomarkers of liver injury in rat serum and plasma samples using the Luminex® xMAP® instrument platform. This kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.
Drug toxicity is the leading cause of acute liver failure in the United States. Patients with liver damage generally display elevated amounts of specific liver proteins in serum; these proteins can serve as biomarkers of drug-related liver toxicity. Monitoring these biomarkers can greatly help clinicians avoid drug-induced liver failure. Performing laboratory tests to characterize the side effects of potential therapeutics is an essential part of drug development. The rat is a leading animal model for these pre-clinical toxicity studies. The search for sensitive, organ-specific toxicity biomarkers is complemented by the development of novel assays to measure these critical analytes. Liver-Type Arginase 1 (ARG1), α-glutathione S-transferase (GSTα), and Sorbitol Dehydrogenase (SDH) are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing. Aspartate transaminase 1 (GOT1) and 5′-Nucleotidase / CD73 (5′-NT) are traditional biomarkers recognized by both the Food and Drug Administration (FDA) and its European counterpart, the European Medicines Agency (EMA).
Panel Type: Toxicity
應用
- Analytes: 5′-Nucleotidase (5′-NT/CD73), Liver-Type Arginase 1 (ARG1), Aspartate transaminase 1 (GOT1), α-Glutathione S-Transferase (GSTα), Sorbitol Dehydrogenase (SDH)
- Recommended Sample Type: Rat serum and plasma
- Recommended Sample Dilution: 25 μL per well of 1:25 diluted serum or plasma
- Assay Run Time: 2 hours at room temperature (20-25°C)
- Research Category: Toxicity
特點和優勢
成分
Rat Liver Injury Quality Control 1, 1 vial, lyophilized
Rat Liver Injury Quality Control 2, 1 vial, lyophilized
Assay Buffer, 1 bottle, 30 mL
Wash Buffer, 10X (0.05% Proclin), 2 bottles, 30 mL ea
Rat Liver Injury Detection Antibodies, 1 bottle, 3.2 mL
Streptavidin-Phycoerythrin, 1 bottle, 3.2 mL
Mixing Bottle, 1 bottle
Sample Plate, 96 well format, 1 plate
2 Foil Plate Sealers
其他說明
法律資訊
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
相关内容
See how multiplex assays, such as the Luminex® bead-based multiplex immunoassay MILLIPLEX® Rat Liver Injury Panel, enable researchers to simultaneously measure multiple hepatotoxic biomarkers and cytokines to expand knowledge on drug-induced liver injury processes.
Learn the benefits of using biomarker detection multiplex immunoassays for laboratory, companion, and agricultural animal research and explore MILLIPLEX® multiplex assays for veterinary medicine and animal health research.
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