MABT78
Anti-mouse CD44 (H-CAM) Antibody, clone KM201
clone KM201, from rat
别名:
CD44 antigen (homing function and Indian blood group system), CDw44 antigen, HCAM, H-CAM, HUTCH-1, Phagocytic glycoprotein I, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, Heparan sulfate proteoglycan, Hermes antigen, Hyalu
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所有图片(1)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物源
rat
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
KM201, monoclonal
物種活性
mouse
技術
flow cytometry: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... CD44(960)
一般說明
CD44, also known as H-CAM is a distinct adhesion molecule that, with its 13 known isoforms, comprises a family of transmembrane glycoproteins involved in a wide variety of significant biological processes. Members belonging to this family are involved in apoptosis, migration, metastasis, tumor progression, lymphocyte homing, and the attachment of hematopoietic cells to stromal cells. CD44 is the primary cell surface receptor for hyaluronic acid (HA), and is also a notable target for WNT signaling within the intestinal mucosa. Recent studies have used CD44 marker as a means to isolate different cancer stem cells (CSC) such as; colorectal CSC, pancreatic CSC, and prostate CSC.
特異性
The antibody recognizes CD44 near the hyaluronate binding domain.
免疫原
Epitope: Near the hyaluronate binding domain
Mouse bone marrow-derived stromal cells
應用
Detect mouse CD44 (H-CAM) using this Anti-mouse CD44 (H-CAM) Antibody, clone KM201 validated for use in FC.
Research Category
Cell Structure
Stem Cell Research
Cell Structure
Stem Cell Research
Research Sub Category
Adhesion (CAMs)
Hematopoietic Stem Cells
Adhesion (CAMs)
Hematopoietic Stem Cells
品質
Evaluated by Flow Cytometry in mouse bone marrow cells.
Flow Cytometry Analysis: 0.1 µg of this antibody detected CD44 in mouse bone marrow cells.
Flow Cytometry Analysis: 0.1 µg of this antibody detected CD44 in mouse bone marrow cells.
標靶描述
86 kDa calculated
聯結
Replaces: CBL1308
外觀
Protein G
Format: Purified
Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
Mouse bone marrow cells
Mouse bone marrow cells
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The inhibition of hyaluronan degradation reduced pro-inflammatory cytokines in mouse synovial fibroblasts subjected to collagen-induced arthritis.
Giuseppe M Campo,Angela Avenoso,Angela D'Ascola,Michele Scuruchi,Vera Prestipino et al.
Journal of Cellular Biochemistry null
Giuseppe M Campo et al.
Innate immunity, 19(5), 462-478 (2013-01-04)
Investigations have suggested degradation of native hyaluronan (HA) into small oligosaccharides as being involved in the development and progression of inflammatory diseases, particularly rheumatoid arthritis (RA). Inflammatory responses occur by modulating the TLR4 and 2, and the CD44 natural HA
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