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Merck
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主要文件

MABS1228

Sigma-Aldrich

Anti-ANKRD1/CARP Antibody, clone 12G8.2

clone 12G8.2, from mouse

别名:

Ankyrin repeat domain-containing protein 1, Cardiac ankyrin repeat protein, Cytokine-inducible gene C-193 protein, Cytokine-inducible nuclear protein

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

12G8.2, monoclonal

物種活性

rat, human

技術

immunohistochemistry: suitable (paraffin)
western blot: suitable

同型

IgG1κ

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... ANKRD1(27063)

一般說明

Ankyrin repeat domain-containing protein 1 (UniProt Q15327; also known as Cardiac ankyrin repeat protein, Cytokine-inducible gene C-193 protein, Cytokine-inducible nuclear protein) is encoded by the ANKRD1 (also known as C193, CARP, HA1A2) gene (Gene ID 27063) in human. ANKRD1/CARP belongs to a family of conserved muscle ankyrin repeat proteins (MARPs), members of which also include ANKRD2 and diabetes ankyrin repeat protein (DARP, ANKRD23). ANKRD1 is highly expressed in cardiomyocytes and known to interact with myopalladin and titin, implicating its roles in myopalladin complex-dependent sarcomere integrity maintenance and stress-induced gene regulations medidated by the titin complex. ANKRD1 is up-regulated in patients with dilated cardiomyopathy and in animal models of cardiac hypertrophy induced by pressure overload and adrenergic stimulation. ANKRD1 is shown to regulate the hypertrophic agonist phenylephrine-/PE-induced α-adrenergic signaling pathway in neonatal rat ventricular myocytes, where it recruits and localizes ERK1/2 and GATA4 in a sarcomeric complex, resulting in enhanced GATA4 phosphorylation and subsequent ANKRD1 complex nuclear translocation and gene activation.

免疫原

Epitope: Ankyrin repeats 4&5.
GST-tagged recombinant human ANKRD1/CARP fragment corresponding ankyrin repeats 4&5.

應用

Anti-ANKRD1/CARP Antibody, clone 12G8.2 is an antibody against ANKRD1/CARP for use in Western Blotting, Immunohistochemistry (Paraffin).
Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected ANKRD1/CARP in human and rat heart tissue sections.

品質

Evaluated by Western Blotting in human heart tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected ANKRD1/CARP in 10 µg of human heart tissue lysate.

標靶描述

~37 kDa observed. 36.25 kDa calculated. Uncharacterized band(s) may appear in some lysates.

外觀

Format: Purified

其他說明

Concentration: Please refer to lot specific datasheet.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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