推荐产品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
12G8.2, monoclonal
物種活性
rat, human
技術
immunohistochemistry: suitable (paraffin)
western blot: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... ANKRD1(27063)
一般說明
Ankyrin repeat domain-containing protein 1 (UniProt Q15327; also known as Cardiac ankyrin repeat protein, Cytokine-inducible gene C-193 protein, Cytokine-inducible nuclear protein) is encoded by the ANKRD1 (also known as C193, CARP, HA1A2) gene (Gene ID 27063) in human. ANKRD1/CARP belongs to a family of conserved muscle ankyrin repeat proteins (MARPs), members of which also include ANKRD2 and diabetes ankyrin repeat protein (DARP, ANKRD23). ANKRD1 is highly expressed in cardiomyocytes and known to interact with myopalladin and titin, implicating its roles in myopalladin complex-dependent sarcomere integrity maintenance and stress-induced gene regulations medidated by the titin complex. ANKRD1 is up-regulated in patients with dilated cardiomyopathy and in animal models of cardiac hypertrophy induced by pressure overload and adrenergic stimulation. ANKRD1 is shown to regulate the hypertrophic agonist phenylephrine-/PE-induced α-adrenergic signaling pathway in neonatal rat ventricular myocytes, where it recruits and localizes ERK1/2 and GATA4 in a sarcomeric complex, resulting in enhanced GATA4 phosphorylation and subsequent ANKRD1 complex nuclear translocation and gene activation.
免疫原
Epitope: Ankyrin repeats 4&5.
GST-tagged recombinant human ANKRD1/CARP fragment corresponding ankyrin repeats 4&5.
應用
Anti-ANKRD1/CARP Antibody, clone 12G8.2 is an antibody against ANKRD1/CARP for use in Western Blotting, Immunohistochemistry (Paraffin).
Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected ANKRD1/CARP in human and rat heart tissue sections.
品質
Evaluated by Western Blotting in human heart tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected ANKRD1/CARP in 10 µg of human heart tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected ANKRD1/CARP in 10 µg of human heart tissue lysate.
標靶描述
~37 kDa observed. 36.25 kDa calculated. Uncharacterized band(s) may appear in some lysates.
外觀
Format: Purified
其他說明
Concentration: Please refer to lot specific datasheet.
未找到合适的产品?
试试我们的产品选型工具.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门