MABN323

Anti-Ermin Antibody, clone 160

clone 160, from mouse

• 别名: Ermin, Juxtanodin
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 160, monoclonal
• 物種活性: mouse, rat
• 技術: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• 同型: IgG2aκ
• NCBI登錄號: NP_084248
• UniProt登錄號: Q5EBJ4
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Ermn(77767)

说明

一般說明

Ermin is also known as Juxtanodin (JN). Ermin is involved in cytoskeletal rearrangements during myelinogenesis and in the maintenance and stability of the myelin sheath in adults. Ermin is also thought to be important in oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the plasticity of related structures in the mature CNS. Ermin is exclusively expressed by oligodendrocytes in the brain and spinal cord, where it appears in the late stages of myelination, and in the mature nerves, it is localized in the outer cytoplasmic lip of the myelin sheath and the paranodal loops.

免疫原

Recombinant protein corresponding to mouse Ermin.

應用

Anti-Ermin Antibody, clone 160 is a highly specific mouse monoclonal antibody, that targets Ermin & has been tested in western blotting, ICC & IHC.

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Ermin in mouse wild type sagittal brain sections, and demonstrated a loss of signal in mouse OL-ablated sagittal brain sections (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-762).

Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Ermin in certain mouse brain and optic nerve sections (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-762).

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

品質

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Ermin in 10 µg of mouse brain tissue lysate.

標靶描述

~42 kDa observed. The calculated molecular weight of this protein is 32 kDa; however, it has been observed at ~42 kDa (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-76.).

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Mouse brain tissue lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable