MABF558

Anti-CD28 Antibody (human), PE, clone CD28.2

clone CD28.2, from mouse

• 别名: T-cell-specific surface glycoprotein CD28, TP44, CD antigen CD28
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: mouse
• 品質等級: 100
• 共軛: PE
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: CD28.2, monoclonal
• 物種活性: human
• 包裝: pkg of 5 μL (0.25 μg/test)
• 技術: flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• 同型: IgG1κ
• UniProt登錄號: P10747
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CD28(940)

说明

一般說明

The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICCOS and BTLA.The CD28.2 antibody may be used as a phenotypic marker for human CD28, expressed on all CD4+ T cells and CD8+ T cells, and is widely used as a reagent for activation of the CD28 receptor in vitro and in vivo. This antibody is also reported to be cross-reactive with several non-human species, including Baboon, Chimpanzee, Cynomolgus, and Rhesus.

This mouse monoclonal antibody Anti-CD28 (human), PE, clone CD28.2 validated for use in IP, IHC & Flow Cytometry for the detection of CD28.

品質

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.25 µg of this antibody detected CD28 in one million human peripheral blood lymphocytes.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: nwg