推荐产品
生物源
rat
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
7C2 (P9C23), monoclonal
物種活性
human, mouse
技術
immunohistochemistry: suitable
western blot: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... PAX9(5083)
一般說明
Paired box protein Pax-9 (UniProt P47242; also known as Paired box gene 9) is encoded by the Pax9 gene (Gene ID 18511) in murine species. Pax9 belongs to a family of nine transcription factors (Pax1-9) characterized by the presence of a DNA-binding ‘paired’-domain. Pax family transcription factors regulate the morphogenesis of a wide range of organs and are key factors for the development of mammalian sensory organs such as the eye (Pax6, Pax2), nose (Pax6), ears (Pax2, Pax8), and the endoderm-derived taste papillae (Pax9). In addition, Pax9 expression in the normal epithelium of the adult human oesophagus is reported to be either lost or significantly reduced in the majority of invasive carcinomas and epithelial dysplasias (precancerous lesions). The drop in the percentage of Pax9-positive cells in the epithelium decreases with increasing malignancy of the epithelial lesion.
免疫原
MBP-tagged recombinant protein corresponding to the C-terminal region of mouse Pax-9.
應用
Anti-Pax-9 Antibody, clone 7C2 (P9C23), Cat. No. MABE1041, is a highly specific rat monoclonal antibody, that targets Pax9 and has been tested in Western Blotting.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Pax-9 in 10 µg of HepG2 cell lysate.
Western Blotting Analysis: A representative lot detected Pax-9 in mouse and human oesophagus tissue lysate (Gerber, J.K., et al. (2002). J Pathol. 197(3):293-297).
Immunohistochemistry Analysis: A representative lot detected Pax-9 in mouse and human oesophagus tissue sections (Gerber, J.K., et al. (2002). J Pathol. 197(3):293-297).
Western Blotting Analysis: A representative lot detected Pax-9 in mouse and human oesophagus tissue lysate (Gerber, J.K., et al. (2002). J Pathol. 197(3):293-297).
Immunohistochemistry Analysis: A representative lot detected Pax-9 in mouse and human oesophagus tissue sections (Gerber, J.K., et al. (2002). J Pathol. 197(3):293-297).
品質
Evaluated by Western Blotting in MOLT 4 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected Pax-9 in 10 µg of MOLT 4 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected Pax-9 in 10 µg of MOLT 4 cell lysate.
標靶描述
~36 kDa observed
外觀
Format: Purified
其他說明
Concentration: Please refer to lot specific datasheet.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Josef-Karl Gerber et al.
The Journal of pathology, 197(3), 293-297 (2002-07-13)
Pax genes encode a family of transcription factors that play key roles in embryonic development. Whereas the functions of Pax genes in the adult organism are largely unknown, upregulated Pax gene expression has been implicated in tumourigenesis. In this study
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