MABC1832
Anti-CD44v4 Antibody, clone C44Mab-108
别名:
CDw44, Epican, Extracellular matrix receptor III (ECMR-III) GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, LHR, Phagocytic glycoprotein 1 (PGP-1), Phagocytic glycoprotein I (PGP-I)
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.43
推荐产品
生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
C44Mab-108, monoclonal
分子量
calculated mol wt 82 kDa
observed mol wt ~N/A kDa
純化經由
using protein G
物種活性
human
物種活性（以同源性預測）
monkey
包裝
antibody small pack of 100
技術
ELISA: suitable
flow cytometry: suitable
immunohistochemistry: suitable
western blot: suitable
同型
IgG1κ
表位序列
N-terminal extracellular domain
Protein ID登錄號
UniProt登錄號
儲存溫度
2-8°C
基因資訊
human ... CD44(960)
特異性
Clone C44Mab-108 is a mouse monoclonal antibody that detects CD44v4. It targets an epitope within 19 amino acids from the N-terminal extracellular domain of the protein.
免疫原
KLH-conjugated linear peptide corresponding to 19 amino acids from the N-terminal extracellular domain of human CD44v4.
應用
Quality Control Testing
Evaluated by Flow Cytometry in a CHO cells overexpressing CD44v3-10.
Flow Cytometry Analysis: 1.0 µg of this antibody detected CD44v6 in a one million CHO cells overexpressing CD44v3-10.
Tested Applications
ELISA Analysis: A representative lot detected CD44v4 in ELISA applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).
Western Blotting Analysis: A representative lot detected CD44v4 in Western Blotting applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).
Flow Cytometry Analysis: A representative lot detected CD44v4 in Flow Cytometry applications (Suzuki, H., et al. (2023). Curr Issues Mol Biol. 45(3):1875-1888).
Immunohistochemistry Applications: A representative lot detected CD44v4 in Immunohistochemistry applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
Evaluated by Flow Cytometry in a CHO cells overexpressing CD44v3-10.
Flow Cytometry Analysis: 1.0 µg of this antibody detected CD44v6 in a one million CHO cells overexpressing CD44v3-10.
Tested Applications
ELISA Analysis: A representative lot detected CD44v4 in ELISA applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).
Western Blotting Analysis: A representative lot detected CD44v4 in Western Blotting applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).
Flow Cytometry Analysis: A representative lot detected CD44v4 in Flow Cytometry applications (Suzuki, H., et al. (2023). Curr Issues Mol Biol. 45(3):1875-1888).
Immunohistochemistry Applications: A representative lot detected CD44v4 in Immunohistochemistry applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
標靶描述
CD44 antigen (UniProt: P16070; also known as CDw44, Epican, Extracellular matrix receptor III (ECMR-III), GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1 (PGP-1), Phagocytic glycoprotein I (PGP-I)) is encoded by the CD44 (also known as LHR, MDU2, MDU3, MIC4) gene (Gene ID: 960) in human. CD44 is a Type 1 transmembrane glycoprotein involved in cell adhesion, migration, and proliferation. It also plays a role in lymphocyte activation, tumor metastasis, and wound healing. It is encoded by the CD44 gene, and it is expressed in a wide range of cell types. The protein′s structure includes a hyaluronic acid (HA) binding domain, a stem region, and a variable extracellular domain. Alternative splicing may produce 19 isoforms. CD44 splice variants (CD44v) play a role in tumorigenesis and malignancy. It is also implicated in various other diseases, including autoimmune disorders, cardiovascular diseases and fibrosis.
外觀
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
重構
0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
儲存和穩定性
Recommended storage: +2°C to +8°C.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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