推荐产品
生物源
mouse
品質等級
抗體表格
culture supernatant
抗體產品種類
primary antibodies
無性繁殖
P3 II-26, monoclonal
物種活性
human
製造商／商標名
Chemicon®
技術
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同型
IgG2b
適合性
not suitable for immunohistochemistry (Paraffin)
UniProt登錄號
運輸包裝
wet ice
基因資訊
human ... ABCB4(5244)
特異性
This antibody reacts with an internal epitope of MDR3 P-gp. It does not cross-react with the human MDR1 P-gp. It has been reported that this clone also cross reacts with mouse MDR2 Pgp {Kok et al 2003 {http://www.biochemj.org/bj/369/0539/3690539.pdf}.
免疫原
Mab was selected after immunization with a fusion protein consisting of Gluthatione-S-Transferase and a fragment of MDR3 P-gp comprising aa 629-692.
應用
Anti-MDR3 Antibody, clone P3 II-26 is an antibody against MDR3 for use in WB, IC, IH.
Western Blotting: MDR3 is a 140 kDa protein.
Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone-fixed frozen sections
Not suitable for paraffin-embedded tissues
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone-fixed frozen sections
Not suitable for paraffin-embedded tissues
Optimal working dilutions must be determined by end user.
儲存和穩定性
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
Tineke Kok et al.
The Biochemical journal, 369(Pt 3), 539-547 (2002-10-17)
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that controls expression of genes involved in lipid metabolism and is activated by fatty acids and hypolipidaemic fibrates. Fibrates induce the hepatic expression of murine multidrug resistance 2 ( Mdr2 )
G J Hooiveld et al.
Gastroenterology, 117(3), 678-687 (1999-08-28)
Biliary cholesterol secretion is coupled to that of phospholipids in a process controlled by mdr2 P-glycoprotein activity and bile salt secretion. Statins, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been shown to affect hepatobiliary lipid secretion in rats. The aim
Maria Paprocka et al.
European journal of haematology, 99(5), 415-422 (2017-08-15)
It is well established that expression of multi-drug resistance (MDR) proteins (MDR1, BCRP, MDR3, MRP1, and LRP) in leukemic blasts correlates with acute myeloid leukemia (AML) patients' clinical response. Assuming that leukemic stem cells (LSC) are resistant to chemotherapy and
G L Scheffer et al.
Cancer research, 60(18), 5269-5277 (2000-10-04)
Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1 P-glycoprotein (P-gp) or the multidrug resistance protein 1 (MRP1). MDR3 P-gp is a close homologue of MDR1 P-gp
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