推荐产品
生物源
mouse
品質等級
共軛
saporin
抗體產品種類
primary antibodies
無性繁殖
192, monoclonal
物種活性
rat
應無反應活性
mouse, human
製造商／商標名
Chemicon®
技術
immunolesioning: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
目標翻譯後修改
unmodified
基因資訊
human ... NGFR(4804)
特異性
Rat NGF receptor. MAB365 is the monoclonal antibody used for MAB390-SAP
應用
Anti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 is an antibody against p75 Low Affinity Nerve Growth Factor Receptor for use in 0.
Immunotoxin (see "Protocols" for Technical Notes)
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurochemistry & Neurotrophins
Neurodegenerative Diseases
Neurochemistry & Neurotrophins
外觀
Saporin Conjugated. 192-IgG-SAP is sterile filtered and presented in Dulbecco′s PBS with no preservative.
儲存和穩定性
Centrifuge material at low speed in microfuge to ensure all of the solution is at the bottom of the tube. Vortex gently. Long term storage at -70ºC or below. Short term storage at -20ºC or 2-8ºC with appropriate antibacterial agent if compatible with the intended application. The sterile conjugate is stable at 2-8ºC for several months. Avoid repeated freezing and thawing. Glycerol (1:1) can be added for additional stability if compatible with the intended application. This immunotoxin may be handled safely using standard laboratory procedures as the cross-species reactivity between these anti-rat p75 antibodies and the human form of p75 is negligible.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Selective immunolesions of hippocampal cholinergic input fail to impair spatial working memory.
McMahan, R W, et al.
Hippocampus, 7, 130-136 (1997)
M M Nicolle et al.
Neuroscience, 77(3), 649-659 (1997-04-01)
Lesion models in the rat were used to examine the effects of removing innervation of the hippocampal formation on glutamate receptor binding in that system. Bilateral aspiration of the entorhinal cortex was used to remove the cortical innervation of the
Toxin-induced death of neurotrophin-sensitive neurons.
R G Wiley
Methods in molecular biology (Clifton, N.J.), 169, 217-222 (2001-01-06)
Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor.
Heckers, S, et al.
The Journal of Neuroscience, 14, 1271-1289 (1994)
J J Waite et al.
Neuroscience, 65(2), 463-476 (1995-03-01)
Immunolesions of the cholinergic basal forebrain were produced in rats using various intraventricular doses of the immunotoxin 192 immunoglobulin G-saporin: 0.34, 1.34, 2.0, 2.7 and 4.0 micrograms/rat. A battery of behavioral tests, chosen on the basis of reported sensitivity to
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