推荐产品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
4AT44, monoclonal
物種活性
mouse, human
製造商／商標名
Chemicon®
技術
western blot: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... MET(4233)
mouse ... Met(17295)
特異性
Reacts with c-met/HGFR (Hepatocyte growth factor receptor). The Met receptor tyrosine kinase is the prototypical member of a small subfamily of growth factor receptors that when activated, induces mitogenic, motogenic, and morphogenic cellular responses. The ligand for c-met is hepatocyte growth factor/scatter factor (HGF/SF) and while normal HGF/SF-Met signaling is required for embryonic development, abnormal c-met signaling has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes.
免疫原
Purified recombinant catalytic domain of human Met
應用
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
This Anti-c-met Antibody, clone 4AT44 is validated for use in WB for the detection of c-met.
Western Blot: 1:100-1:500.
ELISA (direct): 1:1,000
Optimal working dilutions must be determined by the end user.
ELISA (direct): 1:1,000
Optimal working dilutions must be determined by the end user.
聯結
Replaces: 04-1051
外觀
Format: Purified
Protein G purified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.
儲存和穩定性
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings.
Knudsen, BS; Zhao, P; Resau, J; Cottingham, S; Gherardi, E; Xu, E; Berghuis, B; Daugherty et al.
Applied Immunohistochemistry & Molecular Morphology null
Antibody validation by quantitative analysis of protein expression using expression of Met in breast cancer as a model.
Pozner-Moulis, S; Cregger, M; Camp, RL; Rimm, DL
Laboratory Investigation; a Journal of Technical Methods and Pathology null
Wafaa M Rashed et al.
Journal of cancer research and clinical oncology, 147(1), 167-175 (2020-09-28)
Long interspersed nuclear element 1 (LINE-1 or L1) is a dominant non-long terminal repeat (non-LTR) retrotransposon in the human genome that has been implicated in the overexpression of MET. Both the canonical MET and L1-MET transcripts are considered to play
Simone Buraschi et al.
The Journal of biological chemistry, 285(53), 42075-42085 (2010-10-27)
A theme emerging during the past few years is that members of the small leucine-rich proteoglycan gene family affect cell growth by interacting with multiple receptor tyrosine kinases (RTKs), mostly by a physical down-regulation of the receptors, thereby depriving tumor
Xiaobin Wang et al.
Journal of cellular and molecular medicine, 25(21), 10164-10174 (2021-10-16)
Mantle cell lymphoma (MCL) is a haematologic malignancy. The proteasome inhibitor (PI) bortezomib has been approved to treat MCL, but resistance has emerged through mechanisms that remain unclear. This study aimed to explore the mechanism of PI resistance in MCL
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