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Key Documents

MAB2253Z

Sigma-Aldrich

Anti-Integrin β1 Antibody, clone 6S6, Azide Free

clone 6S6, Chemicon®, from mouse

别名:

CD29

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

6S6, monoclonal

物種活性

human

製造商/商標名

Chemicon®

技術

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

同型

IgG1

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... ITGB1(3688)

一般說明

Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.

特異性

Reacts with the human integrin beta1 subunit. Specificity verified by preclearing of beta1in immunoprecipitation, flow cytometry on transfectant cells displaying human beta1 integrin, and reactivity with purified beta1. Similar in behavior and characteristics to antibody clone 3S3 (Wilkins et al., 1996).

免疫原

Human synovial cells

應用

Anti-Integrin β1 Antibody, clone 6S6, Azide Free detects level of Integrin β1 & has been published & validated for use in FC, IH & IP.
Immunoprecipitation

Immunohistochemistry on frozen sections

Flow cytometry

Blocks adhesion of cells to extracellular matrix proteins

Induces aggregation of certain lymphoid cells

Does not bind reduced beta.1 integrin on Western blot

Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
Integrins

標靶描述

88 kDa

外觀

Protein A purified
Format: Purified
Protein A Purified mouse immunoglobulin in PBS, no preservatives.

儲存和穩定性

Maintain 6 months at 4°C, from date of shipment. Do not freeze. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

分析報告

Control
Tonsil, human skin tissue

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly.
Somanath, PR; Kandel, ES; Hay, N; Byzova, TV
The Journal of Biological Chemistry null
Adipocyte functions are modulated by cell size change: potential involvement of an integrin/ERK signalling pathway.
Farnier, C; Krief, S; Blache, M; Diot-Dupuy, F; Mory, G; Ferre, P; Bazin, R
International Journal of Obesity null
Src kinase mediates productive endocytic sorting of reovirus during cell entry.
Mainou, BA; Dermody, TS
Journal of virology null
Alteration of integrin-dependent adhesion and signaling in EMT-like MDCK cells established through overexpression of calreticulin.
Yoshito Ihara,Yoko Inai,Midori Ikezaki
Journal of Cellular Biochemistry null
Francois Lehembre et al.
The EMBO journal, 27(19), 2603-2615 (2008-09-06)
Loss of expression of the cell-cell adhesion molecule E-cadherin is a hallmark of epithelial-mesenchymal transition (EMT) in development and in the progression from epithelial tumours to invasive and metastatic cancers. Here, we demonstrate that the loss of E-cadherin function upregulates

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