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product name
Human Total Proinsulin ELISA, This Human Total Proinsulin ELISA is used to measure & quantify Proinsulin levels in Metabolism & Endocrine & Cell Signaling research.
品質等級
物種活性
human
包裝
kit of 1 × 96 wells
參數
20 μL sample volume (4hr assay)
assay range
accuracy: 88-103%
linearity: 84-120%
sensitivity: 0.5 pM
standard curve range: 2-200 pM
技術
ELISA: suitable
輸入
sample type serum
sample type plasma (K2 EDTA)
NCBI登錄號
UniProt登錄號
應用
research use
檢測方法
colorimetric (450nm)
運輸包裝
wet ice
儲存溫度
2-8°C
一般說明
Proinsulin, the precursor of insulin and C-peptide, is made by the β cells of the pancreas. Proinsulin formed by the cleavage of pre-proinsulin contains B- and A-domains linked through the connecting domain. Proinsulin interacts with insulin receptor-A (IR-A) isoform present in the nervous system and exhibits antiapoptotic and neuroprotective effects in the developing and postnatal nervous system. Elevated levels of proinsulin serve as a marker for secretory β-cell dysfunction. Increased levels of this hormone are also observed in patients with type 2 diabetes and impaired glucose tolerance. This kit measures the intact and intermediate metabolic forms of human proinsulin.
應用
Human Total Proinsulin ELISA has been used to measure plasma, serum, eye, and retinal levels of human proinsulin.
其他說明
Research Sub Category
Obesity
Metabolic Disorders
Research Category
Metabolism
20 μL sample volume 3 hour assay, room temperature
Obesity
Metabolic Disorders
Research Category
Metabolism
20 μL sample volume 3 hour assay, room temperature
免責聲明
For research use only. Not for use in diagnostic procedures.
訊號詞
Warning
危險聲明
危險分類
Met. Corr. 1 - Skin Sens. 1
儲存類別代碼
8A - Combustible, corrosive hazardous materials
水污染物質分類（WGK）
WGK 3
Michael A Weiss
The Journal of biological chemistry, 284(29), 19159-19163 (2009-04-28)
Insulin plays a central role in the regulation of vertebrate metabolism. The hormone, the post-translational product of a single-chain precursor, is a globular protein containing two chains, A (21 residues) and B (30 residues). Recent advances in human genetics have
Carolina Isiegas et al.
Investigative ophthalmology & visual science, 57(8), 3610-3618 (2016-07-09)
The induction of proinsulin expression by transgenesis or intramuscular gene therapy has been shown previously to retard retinal degeneration in mouse and rat models of retinitis pigmentosa (RP), a group of inherited conditions that result in visual impairment. We investigated
Flora de Pablo et al.
Frontiers in molecular neuroscience, 11, 426-426 (2018-12-12)
Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied
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