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Key Documents

ABS552

Sigma-Aldrich

Anti-p40 Antibody

from rabbit, purified by affinity chromatography

别名:

Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

100
300

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

human

物種活性(以同源性預測)

mouse (based on 100% sequence homology)

技術

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... TP63(8626)

一般說明

p40, also known as Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor , KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, or p51, and encoded by the gene TP63/KET/P63/P73H/P73L/TP73L, is a member of the p53 protein family. p40 is a sequence specific DNA binding transcriptional activator or repressor depending upon the target gene and the isoform involved. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specificactivity. p40 is involved in Notch signaling and plays a role in p53/TP53 dependent apoptosis and epithelial morphogenesis. Moreover p40, developmentally, is required for proper limb formation. p40 is expressed widely, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. Mutations in p40 lead to a variety of dysplasias and malformations, including Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome), Ankyloblepharon-ectodermal defects cleft lip/palate disorder (AEC), Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), Split-hand/foot malformation 4 (SHFM4), Limb-mammary syndrome (LMS), Ectodermal dysplasia, Rapp-Hodgkin type (EDRH), Non-syndromic orofacial cleft 8 (OFC8).

特異性

Uniprot describes multiple isoforms for this protein and based on the immunogen this antibody should recognize isoforms 2,4,6,8,10 and 12.

免疫原

Epitope: Transcription activation domain
KLH-conjugated linear peptide corresponding to the transcription activation domain of human p40.

應用

Anti-p40 | ABS552 is an antibody against p40 for use in Western Blotting, Immunohistochemistry (Paraffin).
Research Category
Signaling
Research Sub Category
Signaling Neuroscience
Western Blotting Analysis: 2.0 µg/mL from a representative lot detected p40 in 10 µg of human liver and human skin tissue lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Isocitrate dehydrogenase in squamous carcinoma cells.

品質

Evaluated by Western Blotting in human heart tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected p40 in 10 µg of human heart tissue lysate.

標靶描述

~63/56/51/46 kDa observed. Uncharacterized band(s) may appear in some lysates.

外觀

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Kuijie Liu et al.
Oncotarget, 8(17), 29101-29115 (2017-04-19)
Among the diverse co-regulatory relationships between transcription factors (TFs) and microRNAs (miRNAs), feedback loops have received the most extensive research attention. The co-regulation of TFs and miRNAs plays an important role in colorectal cancer (CRC) growth. Here, we show that
Theresa Casey et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 311(6), R1125-R1134 (2016-10-07)
Circadian clocks influence virtually all physiological processes, including lactation. Here, we investigate the role of the CLOCK gene in regulation of mammary epithelial cell growth and differentiation. Comparison of mammary morphology in late-pregnant wild-type and ClockΔ19 mice, showed that gland

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