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Merck
所有图片(2)

主要文件

ABN241

Sigma-Aldrich

抗-GluR1抗体

from rabbit, purified by affinity chromatography

别名:

Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

human, mouse, rat

技術

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... GRIA1(2890)
mouse ... Gria1(14799)
rat ... Gria1(50592)

一般說明

谷氨酸受体(GluRs)是一个多样化的群体,负责介导脊椎动物中枢神经系统中的大多数兴奋性突触传递。它们可以分为离子型或代谢型,并可再根据其激动剂的偏好型(NMDA、AMPA或红藻氨酸)而进一步分类。存在有四种类型的AMPA选择性GluR亚基(GluR1、GluR2、GluR3和GluR4)。不同亚基的四聚体或五聚体组合有助于AMPA受体的功能多样性。AMPA受体可在大多数兴奋性突触中介导快速突触电流,具有以亚型组成为特征的化学计量。控制钙渗透性的关键残基位于孔环区域。在GluR1、GluR3和GluR4中,该位置被一个Gln残基所占据。从突触后膜插入或去除GluR1/GluR4寡聚通道似乎是LTP/LTD活性依赖性的,而GluR2/GluR3寡聚体不断循环。

特異性

该抗体识别GluR1的胞外域。

免疫原

对应于大鼠GluR1胞外域的KLH偶联线性肽。

應用

免疫组化分析:代表性批次的1:1,000 的稀释液在人大脑和人小脑组织中检测到GluR1。
抗GluR1抗体是一种高度特异性的兔多克隆抗体,其靶向GluR1&已在蛋白质印迹& IHC(石蜡)中进行了测试。

品質

通过蛋白质印迹对大鼠脑组织裂解液进行了评估。

蛋白质印迹分析:2.0 µg/mL该抗体在10 µg大鼠脑组织裂解液中检测到GluR1。

標靶描述

观察值〜110 kDa

聯結

替代品:PC246-100UG

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Evidence from both human and animal studies demonstrates the importance of social stress in the development of addiction-related behaviour. In rats, intermittent social defeat stress causes long-lasting psychostimulant cross-sensitization. Our recent data reveal heightened expression of AMPA receptor (AMPAR) GluA1
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Crosstalk between G-protein signaling and glutamatergic transmission within the brain reward circuits is critical for long-term emotional effects (depression and anxiety), cravings, and negative withdrawal symptoms associated with opioid addiction. A previous study showed that Regulator of G-protein signaling 4
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