AB3239-I

Anti-Myostatin Antibody, Near CT

from rabbit, purified by affinity chromatography

• 别名: GDF8, Growth/differentiation factor 8, GDF-8, Myostatin
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 物種活性（以同源性預測）: primate (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
• 技術: immunohistochemistry: suitable; western blot: suitable
• NCBI登錄號: NP_005250
• UniProt登錄號: O14793
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... MSTN(2660)

说明

一般說明

Myostatin, also known as Growth/differentiation factor 8, is a negative regulator of skeletal muscle growth encoded by the MSTN (also known as MSLHP and GDF8) gene in human. Myostatin is a member of the bone morphogenetic protein (BMP) family within the TGF-ß superfamily. Growth and differentation factor-associated serum protein-1 & 2 (GASP-1/2) and follistatin-related gene (FLRG) protein are reported to interact with myostatin and negatively regulate its activity (PMID 24019467, 17878677). Mutation in MSTN gene is known to cause muscle hypertrophy (MSLHP), a condition characterized by increased muscle bulk and strength.

免疫原

Epitope: Near C-terminal

KLH-conjugated linear peptide corresponding to human Myostatin near the C-terminal.

應用

Anti-Myostatin Antibody, Near CT is an antibody against Myostatin, Near CT for use in Western Blotting and Immunohistochemistry.

Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected Myostatin in human cardiac myocytes tissue.

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

品質

Evaluated by Western Blotting in human adult heart tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Myostatin in 10 µg of human adult heart tissue lysate.

標靶描述

~31 kDa observed. 30–32 kDa band assumed to be a glycosylated dimer of the carboxy terminus portion of the full length translational product (Artaza, J.N., et al. (2007). J. of Endocrinology. 194:63-76). This antibody also detected the 32-kDa band corresponding to the processed dimer (Artaza, J.N., et al. (2007). J. of Endocrinology. 146(8):3547-3557).

外觀

Affinity

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable