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Key Documents

AB10514P

Sigma-Aldrich

Anti-Serotonin Transporter Antibody

1 mg/mL, from rabbit

别名:

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, sodium-dependent serotonin transporter, serotonin transporter, Solute carrier family 6 member 4, Na+/Cl- dependent serotonin transporter, 5HT transporter, 5-hydroxytryptamine tr

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性(以同源性預測)

sheep (100% homology), rat (100% homology), bovine (100% homology), monkey (100% homology), human (100% homology), horse (100% homology), mouse (100% homology), chimpanzee (100% homology)

濃度

1 mg/mL

技術

western blot: suitable

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... HTT(3064)

一般說明

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

特異性

Other species have not been tested.
The antibody reacts with the 70 kDa serotonin transporter protein.

免疫原

Epitope: Center region
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human serotonin transporter.

應用

Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
This Anti-Serotonin Transporter Antibody is validated for use in WB for the detection of Serotonin Transporter.

品質

Western Blot Analysis: 1:1000 dilution of this antibody detected serotonin transporter on human lung lysate.

標靶描述

70 kDa

聯結

Replaces: AB1594P

外觀

Antigen Affinity Purified
Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

儲存和穩定性

Store at 2-8°C for 1 year from date of receipt.

分析報告

Control
Western Blot : Human lung lysate.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Raquel Romay-Tallon et al.
Frontiers in pharmacology, 9, 1149-1149 (2018-10-31)
Naïve depression patients show alterations in serotonin transporter (SERT) and serotonin 2A (5HT2A) receptor clustering in peripheral lymphocytes, and these alterations have been proposed as a biomarker of therapeutic efficacy in major depression. Repeated corticosterone (CORT) induces a consistent depression-like

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