8.03068

N,N-Dimethylformamide dimethyl acetal

for synthesis

• 别名: N,N-Dimethylformamide dimethyl acetal, N,N-Dimethyldimethoxymethylamine, DMF-DMA
• 线性分子式: (CH₃O)₂CHN(CH₃)₂
• CAS号: 4637-24-5
• 分子量: 119.16
• MDL號碼: MFCD00008482
• 分類程式碼代碼: 12352116
• 酶委員會索引編號: 225-063-3
• NACRES: NA.22

属性

• 品質等級: 200
• 形狀: liquid
• 自燃溫度: 155 °C
• 效力: >5000 mg/kg LD₅₀, oral (Rat)
• expl. lim.: 1.3-17.7 % (v/v)
• pH值: 7 ( in H₂O)
• mp: -85 °C
• 轉變溫度: flash point 6 °C
• 密度: 0.895 g/cm³ at 20 °C
• 儲存溫度: 2-30°C
• InChI: 1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3/p+1
• InChI 密鑰: ZSXGLVDWWRXATF-UHFFFAOYSA-O

说明

一般說明

N, N-Dimethylformamide dimethyl acetal (DMF-DMA) plays an important role in organic synthesis due to its higher reactivity.

• As a methylating agent, DMF-DMA has been used in the synthesis of methyl esters from acids, methyl ethers, and thioethers from phenols and aromatic thiols.
• DMF-DMA has been used as a formulating agent to synthesize enamines from active methylenes and active methyl groups, and amidines from amines and amides or thioamide.
• It is also possible to produce heterocyclic compounds using DMF-DMA by cyclizing two functional groups.

應用

N,N-Dimethylformamide dimethyl acetal is used:

• In the synthesis of spirooxindole and pyrazole scaffolds via [3+2] cycloaddition reaction of electron-deficient olefins-based pyrazole motif.
• As a reagent in the synthesis of3-acetyl-4-arylquinoline-based enaminones under microwave irradiation.

分析報告

Assay (HClO₄): ≥ 96.0 %
Density (d 20 °C/ 4 °C): 0.893 - 0.897
Identity (IR): passes test

安全信息

• 象形圖: GHS02,GHS05,GHS07,GHS08
• 訊號詞: Danger
• 危險聲明: H225 - H317 - H318 - H332 - H360D
• 防範說明: P210 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• 危險分類: Acute Tox. 4 Inhalation - Eye Dam. 1 - Flam. Liq. 2 - Repr. 1B - Skin Sens. 1
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 42.8 °F
• 閃點（°C）: 6 °C