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613560

Sigma-Aldrich

TMPyP4

A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).

别名:

TMPyP4, meso-5,10,15,20-四-（N-甲基-4-吡啶基）卟啉，四甲苯磺酸盐

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About This Item

经验公式（希尔记法）:
C44H38N8 · C28H28O12S4
CAS号:
36951-72-1
分子量:
1363.60
MDL號碼:
MFCD00013468
分類程式碼代碼:
12352200

品質等級

100

化驗

≥90% (TLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)
protect from light

顏色

purple

溶解度

water: 1 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

InChI

1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3

InChI 密鑰

AKZFRMNXBLFDNN-UHFFFAOYSA-K

一般說明

一种有效的人类端粒酶抑制剂（IC50 = 6.5 µM）。TMPyP4通过堆叠在四链体核心的G-四联体上与DNA四链体紧密结合，导致端粒酶抑制。在四链体DNA存在下发出强烈荧光。
一种有效的人类端粒酶抑制剂（IC50 = 6.5 µM）。TMPyP4通过堆叠在四链体核心的G-四联体上与DNA四链体紧密结合，导致端粒酶抑制。在有四链体DNA存在时发出高荧光。

生化／生理作用

产物不与ATP竞争。
可逆：否
细胞可渗透性：否
靶标IC50：6.5 µM抑制人端粒酶

警告

毒性：标准处理（A）

其他說明

Yamashita, T., et al. 2005.Bioorg.Med. Chem.13, 2433.
Izbicka, E., et al. 1999.Cancer Res. 59, 639.
Anantha, N.V., et al. 1998.Biochemistry 37, 2709.
Arthanari, H., et al. 1998.Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998.J. Am. Chem. Soc.120, 3261.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Sreejana Ray et al.
ACS chemical biology, 15(4), 925-935 (2020-03-29)
Single-stranded DNA (ssDNA) containing four guanine repeats can form G-quadruplex (G4) structures. While cellular proteins and small molecules can bind G4s, it has been difficult to broadly assess their DNA-binding specificity. Here, we use custom DNA microarrays to examine the
Kohji Mori et al.
The Journal of biological chemistry, 297(4), 101120-101120 (2021-08-28)
GGGGCC (G4C2) repeat expansion in the C9orf72 gene has been shown to cause frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Dipeptide repeat proteins produced through repeat-associated non-AUG (RAN) translation are recognized as potential drivers for neurodegeneration. Therefore, selective inhibition of
Ying Yang et al.
PLoS genetics, 17(10), e1009834-e1009834 (2021-10-14)
Stem cells have the potential to maintain undifferentiated state and differentiate into specialized cell types. Despite numerous progress has been achieved in understanding stem cell self-renewal and differentiation, many fundamental questions remain unanswered. In this study, we identify dRTEL1, the
Hannah O Ajoge et al.
Viruses, 14(11) (2022-11-25)
The integration of the HIV-1 genome into the host genome is an essential step in the life cycle of the virus and it plays a critical role in the expression, long-term persistence, and reactivation of HIV expression. To better understand
Margit Dlaska et al.
Cell cycle (Georgetown, Tex.), 12(13), 2084-2099 (2013-06-14)
Immortal cells require a mechanism of telomere length control in order to divide infinitely. One mechanism is telomerase, an enzyme that compensates the loss of telomeric DNA. The second mechanism is the alternative lengthening of telomeres (ALT) pathway. In ALT

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