555460-M

Rhosin

≥93% (HPLC), powder, Rho inhibitor, Calbiochem^®

• 别名: Rho抑制剂，Rhosin, G04，(2R)-2-氨基-3-(1H-吲哚-3-基)-Nʹ-((1E)-喹喔啉-6-基亚甲基)丙烷酰肼
• 经验公式（希尔记法）: C₂₀H₁₈N₆O
• CAS号: 1173671-63-0
• 分子量: 358.40
• 分類程式碼代碼: 12352200

属性

• product name: Rho抑制剂，Rhosin, Rho Inhibitor, Rhosin, CAS 1173671-63-0, is a cell-permeable compound that directly targets Rho GEF binding domain (Kd = 354 nM for RhoA), thereby prevents Rho from interacting with its GEFs.
• 品質等級: 100
• 化驗: ≥93% (HPLC)
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: orange-brown
• 溶解度: DMSO: 10 mg/mL
• 儲存溫度: 2-8°C

说明

一般說明

Rhosin is composed of two aromatic rings connected by a linker and binds to the area surrounding Trp58 of RhoA with a Kd in the submicromolar range, effectively inhibiting GEF-catalyzed RhoA activation. This compound is valuable for studying the physiological role of RhoA subfamily GTPases and assessing the therapeutic potential of targeting Rho in pathological conditions.
Moreover, Rhosin can inhibit YAP activation by targeting RhoA and RhoC. It can also suppress tumor cell metastasis by inhibiting the Rho/YAP pathway and modulating the expression of RHAMM and CXCR4 in melanoma and breast cancer cells. It promotes stress resilience by enhancing D1-MSN plasticity and reducing hyperexcitability.

應用

Rho Inhibitor, Rhosin has been used to treat single breast tumor cells to regulate RhoA activity to validate the cell line with the Förster resonance energy transfer (FRET) biosensor.

生化／生理作用

主靶
Rho GT酶

靶标K_i：RhoA为354 nM

警告

毒性：标准处理（A）

重構

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。

其他說明

Shang, X., et al. 2012.Chem. Biol.19, 699.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable