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5.08148

Nefazodone Hydrochloride

Name: Nefazodone Hydrochloride
Brand: MM

别名:

Nefazodone Hydrochloride, 5-HT _2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone, 5-HT_2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone

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About This Item

经验公式（希尔记法）:

C₂₅H₃₂ClN₅O₂ · xHCl

CAS号:

82752-99-6

分子量:

470.01 (free base basis)

MDL號碼:

MFCD00935760

分類程式碼代碼:

12352200

NACRES:

NA.77

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Sigma-Aldrich

N5536

Nefazodone hydrochloride

Sigma-Aldrich

O1141

奥氮平

Y0000553

多沙唑嗪

USP

1643420

替米沙坦相关化合物A

USP

1042930

Articaine Related Compound B

USP

1191000

Dicyclomine hydrochloride

Y0001048

左羟丙哌嗪杂质C

C2460000

氯氮平标准液

USP

1485103

盐酸奥昔布宁

PHL89570

亚细亚皂甙软膏

化驗

≥99% (HPLC)

品質等級

100

形狀

solid

效力

26 nM K_i

製造商／商標名

Calbiochem^®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

ethanol: 10 mM
DMSO: 25 mM

儲存溫度

2-8°C

SMILES 字串

Clc1cc(ccc1)N2CCN(CC2)CCC[n]3nc([n]([c]3=O)CCOc4ccccc4)CC.Cl

InChI

1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

InChI 密鑰

DYCKFEBIOUQECE-UHFFFAOYSA-N

一般說明

A potent 5-HT_2A receptor antagonist (K_d = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (K_d = 48 nM) and 5-HT_1A receptor (K_d = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.

警告

Toxicity: Standard Handling (A)

其他說明

Kim, J.-A. et al. 2012. Toxicol. Lett.214, 175.
Cusack, B. et al. 1994. Psychopharmacol.114, 559.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）