5.06416

Beclin-1 Activator II, retro-inverso TAT-Beclin-1

• 别名: Beclin-1 Activator II, retro-inverso TAT-Beclin-1, (D)-H₂N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO₂H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II
• 经验公式（希尔记法）: C₁₆₄H₂₅₁N₅₇O₄₅
• 分子量: 3741.10
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 化驗: ≥95% (HPLC)
• 品質等級: 100
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: white
• 溶解度: DMSO: 50 mg/mL; water: 50 mg/mL
• 儲存溫度: 2-8°C

说明

一般說明

Tat-beclin 1, a peptide, is derived from a segment of the autophagy protein beclin 1, which binds to human immunodeficiency virus (HIV)-1 Nef. It serves as a potent inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a recently identified negative regulator of autophagy. Tat-beclin 1 has been found to reduce the accumulation of polyglutamine expansion protein aggregates and the replication of various pathogens (including HIV-1) in vitro. Moreover, it has demonstrated the ability to decrease mortality in mice infected with chikungunya or West Nile virus.

生化／生理作用

Cell permeable: yes

Primary Target
GAPR-1/GLIPR2

Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

(D)-H-arg-arg-arg-gln-arg-arg-lys-lys-arg-Gly-tyr~Gly-Gly~thr-Gly-phe-glu-Gly-asp-his-trp-ile-glu-phe-thr-ala-asn-phe-val-asn-thr-OH

外觀

Supplied as a trifluoroacetate salt.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Shoji-Kawata, S., et al. 2013. Nature.494, 201.

法律資訊

Sold under license of US Patent 8,722,628.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable