5.06188

Sertraline Hydrochloride

• 别名: Sertraline Hydrochloride, Serotonin (5-HT) Reuptake Inhibitor, Sertraline, Zoloft
• 经验公式（希尔记法）: C₁₇H₁₇Cl₂N · xHCl
• CAS号: 79559-97-0
• 分子量: 306.23 (free base basis)
• MDL號碼: MFCD00895772
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 化驗: ≥99% (HPLC)
• 品質等級: 100
• 形狀: solid
• 效力: 3.3 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 100 mM; ethanol: 50 mM
• 儲存溫度: 2-8°C
• InChI: 1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
• InChI 密鑰: BLFQGGGGFNSJKA-XHXSRVRCSA-N

说明

一般說明

A very potent uptake inhibitor highly selective for serotonin (K_i = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.

生化／生理作用

Primary Target
5-HT uptake transporter

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.

Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07,GHS08,GHS09
• 訊號詞: Warning
• 危險聲明: H302 - H373 - H410
• 防範說明: P260 - P264 - P273 - P301 + P312 - P314 - P391
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable