5.00667

一磷酸硫胺氯化物 二水合物

EMPROVE^® API

• 别名: 氯化亚氨基磷酸酯
• 经验公式（希尔记法）: C₁₂H₁₈ClN₄O₄PS · 2H₂O
• CAS号: 273724-21-3
• 分子量: 416.82
• Beilstein: 3844977
• MDL號碼: MFCD00063473
• 分類程式碼代碼: 12352107
• 酶委員會索引編號: 208-536-9

属性

• 蒸汽壓力: <1 Pa ( 50 °C)
• 品質等級: 600
• 產品線: EMPROVE^® API
• 形狀: solid
• pH值: 2-3 (20 °C, 100 g/L in H₂O)
• mp: 135 °C (decomposition)
• 溶解度: 176 g/L
• 密度: 1.53 g/cm³ at 20 °C
• 體積密度: 670 kg/m³
• 應用: liquid formulation; pharmaceutical; semi-solid formulation; solid formulation
• 儲存溫度: 2-25°C
• SMILES 字串: [Cl-].Cc1ncc(C[n+]2csc(CCOP(O)(O)=O)c2C)c(N)n1
• InChI: 1S/C12H17N4O4PS.ClH/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19);1H
• InChI 密鑰: GUGWNSHJDUEHNJ-UHFFFAOYSA-N

说明

一般說明

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

應用

Thiamine phosphoric acid ester chloride dihydrate is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Thiamine phosphoric acid ester chloride dihydrate Emprove^® API is manufactured according to ICH Q7 guidelines. An ASMF is available.
This product is part of our proprietary Viscosity Reduction Platform and suitable for highly concentrated protein-based formulations.

法律資訊

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable