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Key Documents

475856

Sigma-Aldrich

线粒体分裂抑制剂，mdivi-1

The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.

别名:

线粒体分裂抑制剂，mdivi-1

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About This Item

经验公式（希尔记法）:
C15H10Cl2N2O2S
CAS号:
338967-87-6
分子量:
353.22
MDL號碼:
MFCD00974506
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥95% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 10 mg/mL

運輸包裝

wet ice

儲存溫度

−20°C

InChI

1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)

InChI 密鑰

NZJKEVWTYMOYOR-UHFFFAOYSA-N

一般說明

一种可渗透细胞的喹唑啉酮化合物，可抑制酵母（Dnm1）和哺乳动物（Drp1）分裂DRP（与发动蛋白相关的GTPases），并以可逆的方式有效诱导线粒体融合成网状结构（在酵母和COS培养物中IC50分别为10和50 M）。无细胞研究表明，mdivi-1通过基于变构调节的机制阻断Dnm1 ATP酶活性（IC50<10 M）和自组装。通过细胞色素C释放评估，Mdivi-1分别在HeLa培养物和无细胞鼠肝线粒体制剂中有效抑制STS和C8-Bid诱导的MOMP（线粒体外膜通透性）。

包裝

用惰性气体包装

警告

毒性：标准处理（A）

其他說明

Cassidy-Stone A., et al. 2008.Dev.Cell14, 193.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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Ann Cassidy-Stone et al.
Developmental cell, 14(2), 193-204 (2008-02-13)
Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mitochondrial fusion proteins attenuate apoptosis by inhibiting release of cytochrome c from mitochondria, in part by controlling cristae structures. Mitochondrial division promotes apoptosis by an unknown mechanism. We
Afzal Misrani et al.
Frontiers in aging neuroscience, 13, 748388-748388 (2021-12-28)
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Mitochondrial dysfunction is thought to be an early event in the onset and progression of AD; however, the precise underlying mechanisms remain unclear. In this study, we investigated mitochondrial proteins
Ghulam Mohammad et al.
Journal of diabetes research, 2022, 3555889-3555889 (2022-04-12)
Mitochondria play a central role in the development of diabetic retinopathy and in the metabolic memory associated with its continued progression. Mitochondria have a regulated fusion fission process, which is essential for their homeostasis. One of the major fission proteins
Yongqi Zhen et al.
Cell death & disease, 13(4), 375-375 (2022-04-21)
Breast cancer is still one of the most common malignancies worldwide and remains a major clinical challenge. We previously reported that the anthelmintic drug flubendazole induced autophagy and apoptosis via upregulation of eva-1 homolog A (EVA1A) in triple-negative breast cancer

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