440025

Luteolin

An antioxidant flavonoid and a free radical scavenger.

• 别名: Luteolin, 3ʹ,4ʹ,5,7-Tetrahydroxyflavone
• 经验公式（希尔记法）: C₁₅H₁₀O₆
• CAS号: 491-70-3
• 分子量: 286.24
• MDL號碼: MFCD00017309
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥90% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: aqueous base: 1.4 mg/mL; DMSO: 7 mg/mL; ethanol: soluble
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
• InChI 密鑰: IQPNAANSBPBGFQ-UHFFFAOYSA-N

说明

一般說明

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

生化／生理作用

Cell permeable: no

Primary Target
rat liver cytosolic glutathione S-transferase activity

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

其他說明

Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable