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Merck
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420294

Sigma-Aldrich

STAT5 Inhibitor II, IQDMA

The STAT5 Inhibitor II, IQDMA controls the biological activity of STAT5.

别名:

STAT5 Inhibitor II, IQDMA, N1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine

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About This Item

经验公式（希尔记法）:
C19H20N4
分子量:
304.39
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥95% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze

顏色

brown

溶解度

DMSO: 50 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

一般說明

A cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Su, J.C., et al. 2009, Life Sci.85, 505.
Chien, C.M., et al. 2008, Chem-Biol. Intr.176, 40.
Yang, S.H., et al. 2008, J. Biochem. Mol. Tox.22, 396.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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